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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 823 - 832 (10page)
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It has been suggested that brain inflammation is important in aggravation of brain damage and/or that inflammation causes neurodegenerative diseases including Parkinson’s disease (PD). Recently, systemic inflammation has also emerged as a risk factor for PD.
In the present study, we evaluated how systemic inflammation induced by intravenous (iv) lipopolysaccharides (LPS) injection affected brain inflammation and neuronal damage in the rat. Interestingly,almost all brain inflammatory responses, including morphological activation of microglia, neutrophil infiltration,and mRNA/protein expression of inflammatory mediators, appeared within 4-8 h, and subsided within 1-3 days, in the substantia nigra (SN), where dopaminergic neurons are located. More importantly, however,dopaminergic neuronal loss was not detectable for up to 8 d after iv LPS injection. Together, these results indicate that acute induction of systemic inflammation causes brain inflammation, but this is not sufficiently toxic to induce neuronal injury.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Aktan F / 2004 / iNOS-mediated nitric oxide production and its regulation / Life Sci 75 : 639 ~ 653
Altman R / 2008 / Inhibition of vascular inflammation by dehydroepiandrosterone sulfate in human aortic endothelial cells: roles of PPARalpha and NF-kappaB / Vascul Pharmacol
Batchelor PE / 1999 / Activated macrophages and microglia induce dopaminergic sprouting in the injured striatum and express brain-derived neurotrophic factor and glial cell l
Blum-Degen D / 1995 / Interleukin-1 beta and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients / Neurosci Lett 202
Bogdan C / 2001 / Nitric oxide and the immune response / Nat Immunol 2 : 907 ~ 916
Altman R / 2008 / Inhibition of vascular inflammation by dehydroepiandrosterone sulfate in human aortic endothelial cells: roles of PPARalpha and NF-kappaB / Vascul Pharmacol
Batchelor PE / 1999 / Activated macrophages and microglia induce dopaminergic sprouting in the injured striatum and express brain-derived neurotrophic factor and glial cell l
Blum-Degen D / 1995 / Interleukin-1 beta and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients / Neurosci Lett 202
Bogdan C / 2001 / Nitric oxide and the immune response / Nat Immunol 2 : 907 ~ 916
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