메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류
인문학
인문학 일반 역사학 철학 종교학 어문학 기타 인문학
사회과학
사회과학 일반 경영학 관광학 교육학 군사학 문헌정보학 법학 사회학 신문방송학 심리과학 정치외교학 지리학 행정학 경제학 무역학 인류학 기타 사회과학
자연과학
자연과학 일반 물리학 생물학 생활과학 수학·통계학 천문학 지구과학 화학 기타 자연과학
공학
공학 일반 건축공학 기계공학 산업공학 재료·에너지공학 전기전자공학 조선해양공학 화학공학 컴퓨터학 기타공학
의약학
의학 일반 간호학 수의학 약학 한의학 기초의학 임상의학 기타 의약학
농수해양학
농수해양학 일반 농학 수산학 식품과학 임학 축산학 해상운송학 기타 농수해양학
예술체육학
예술 일반 디자인 미술 미용 사진 음악학 의상 체육 공연매체예술 기타 예술체육학
복합학
학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

ENG

추천
검색

논문 기본 정보

자료유형
학술저널
저자정보
Lee, Bom-Bi (Acupuncture and Meridian Science Research Center, College of Oriental Medicine, Kyung Hee University) Sur, Bong-Jun (The Graduate School of Basic Science of Oriental Medicine, College of Oriental Medicine, Kyung Hee University) Cho, Se-Hyung (Department of Physiology, Neurodegeneration Control Research Center, Kyung Hee University School of Medicine) Yeom, Mi-Jung (Acupuncture and Meridian Science Research Center, College of Oriental Medicine, Kyung Hee University) Shim, In-Sop (Acupuncture and Meridian Science Research Center, College of Oriental Medicine, Kyung Hee University) Lee, Hye-Jung (Acupuncture and Meridian Science Research Center, College of Oriental Medicine, Kyung Hee University) Hahm, Dae-Hyun (Acupuncture and Meridian Science Research Center, College of Oriental Medicine, Kyung Hee University)
저널정보
한국통합생물학회 Animal cells and systems Animal cells and systems 제16권 제4호
발행연도
2012.1
수록면
302 - 312 (11page)

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색

초록· 키워드

오류제보하기
The purpose of this study was to examine whether Phellodendri Cortex extract (PCE) could improve learning and memory impairments caused by lipopolysaccharide (LPS)-induced inflammation in the rat brain. The effect of PCE on modulating pro-inflammatory mediators in the hippocampus and its underlying mechanism were investigated. Injection of LPS into the lateral ventricle caused acute regional inflammation and subsequent deficits in spatial learning ability in the rats. Daily administration of PCE (50, 100, and 200 mg/kg, i.p.) for 21 days markedly improved the LPS-induced learning and memory disabilities in the Morris water maze and passive avoidance test. PCE administration significantly decreased the expression of pro-inflammatory mediators such as tumor necrosis factor-${\alpha}$, interleukin-$1{\beta}$, and cyclooxygenase-2 mRNA in the hippocampus, as assessed by RT-PCR analysis and immunohistochemistry. Together, these findings suggest that PCE significantly attenuated LPS-induced spatial cognitive impairment through inhibiting the expression of pro-inflammatory mediators in the rat brain. These results suggested that PCE may be effective in preventing or slowing the development of neurological disorders, including Alzheimer's disease, by improving cognitive and memory function because of its anti-inflammation activity in the brain.
#lipopolysaccharide #memory #inflammation #Phellodendri Cortex #Morris water maze

목차

등록된 정보가 없습니다.

참고문헌 (37)

참고문헌 신청
Collister KA / 2005 / Potential therapeutic targets in the NF-kappaB pathway for Alzheimer’s disease / Drug News Perspect 18:623~629 google schola Cunningham C / 2009 / Systemic inflammation induces acute behavioral and cognitive changes and accelerates neurodegenerative disease / Biol Psych 65:304~312 google schola Fehe´r A / 2010 / Association study of interferon-g, cytosolic phospholipase A2, and cyclooxygenase-2 gene polymorphisms in Alzheimer disease / Am J Geriatr Psych 18:983~987 google schola Frank-Cannon TC / 2009 / Does neuroinflammation fan the flame in neurodegenerativediseases? / Mol Neurodegener 16:47~59 google schola Fujimi K / 2007 / Altered expression of COX-2 in subdivisions of the hippocampus during aging and in Alzheimer’s disease : the Hisayama Study / Dement Geriatr Cogn Disord 23:423~431 google schola

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0