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논문 기본 정보

자료유형
학술저널
저자정보
Zahid Manzoor (Jeju National University) Jung Eun Koo (Jeju National University) Young-Sang Koh (Jeju National University)
저널정보
대한미생물학회 JOURNAL OF BACTERIOLOGY AND VIROLOGY JOURNAL OF BACTERIOLOGY AND VIROLOGY Vol.44 No.4
발행연도
2014.12
수록면
297 - 304 (8page)

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초록· 키워드

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The role of mitogen-activated protein kinases (MAPKs) in regulation of inflammation is well known. MAPK family is activated by various stimuli and involved in transmitting extracellular signals to nucleus leading to gene regulation. Inflammation is primary defensive response of host against microbes. Controlled inflammation is helpful and indispensable for host defense. However, uncontrolled inflammatory response leads to various inflammatory diseases and cancer. Persistent inflammation leads to cell proliferation and survival that plays crucial role in tumorigenesis. In this review, we recapitulate the recent knowledge of MAPK signaling and its roles in inflammation-associated carcinogenesis.

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INTRODUCTION
Mitogen-activated Protein Kinases
ERK MAPKs and Cancer Development
JNK MAPKs and Cancer Development
p38 MAPKs and Cancer Development
Inflammation and Caner Development
Conclusion and Perspective
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UCI(KEPA) : I410-ECN-0101-2016-475-000966449