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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 371 - 377 (7page)
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When treated with protopine and alkalized extracts of the tuber of Corydalis ternata for one year, significant decrease in glutamate level and increase in glutamate dehydrogenase (GDH) activity was observed in rat brains. The expression of GDH between the two groups remained unchanged as determined by Western and Northern blot analysis, suggesting a post-translational regulation of GDH activity in alkalized extracts treated rat brains. The stimulatory effects of alkalized extracts and pro - topine on the GDH activity was further examined in vitro with two types of human GDH isozymes, hGDH1 (house-keeping GDH) and hGDH2 (nerve-specific GDH). Alkalized extracts and protopine activated the human GDH isozymes up to 4.8-fold. hGDH2 (nervespecific GDH) was more sensitively affected by 1 mM ADP than hGDH1 (house-keeping GDH) on the activation by alkalized extracts. Studies with cassette mutagenesis at ADP-binding site showed that hGDH2 was more sensitively regulated by ADP than hGDH1 on the activation by Corydalis ternata. Our results suggest that prolonged exposure to Corydalis ternata may be one of the ways to regulate glutamate concentration in brain through the activation of GDH.
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참고문헌 (30)
참고문헌 신청
[학술지(
/ / Amino acid analysis by reverse-phase high-performance liquid chromatographprecolumnderivatization with phenylisothiocyanate 136 : 65 ~ 74
/ / An assessment of thepotential of protopine to inhibit microsomal drug metabolisingenzymes and prevent chemical-induced hepatotoxicity inrodents : 215 ~ 9
/ / Antiinflammatoryactivities of methanolic extract and alkyalodalcomponents from Corydalis tuber : 262 ~ 5
/ / Birth and adaptive evolution of ahominoid gene that supports high neurotransmitter flux : 1061 ~ 3
/ / Amino acid analysis by reverse-phase high-performance liquid chromatographprecolumnderivatization with phenylisothiocyanate 136 : 65 ~ 74
/ / An assessment of thepotential of protopine to inhibit microsomal drug metabolisingenzymes and prevent chemical-induced hepatotoxicity inrodents : 215 ~ 9
/ / Antiinflammatoryactivities of methanolic extract and alkyalodalcomponents from Corydalis tuber : 262 ~ 5
/ / Birth and adaptive evolution of ahominoid gene that supports high neurotransmitter flux : 1061 ~ 3
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