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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 408 - 417 (10page)
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Trimellitic anhydride (TMA) is widely used indu-strially to make epoxy and alkyd resins, plasticizers and surfactants. The purpose of this study was to investigate whether contact hypersensitivity (CHS) is induced by repeated TMA challenge and the role of TNF-α and IgE in the TMA-induced CHS. The repetition of the challenge enlarged the extent of an early and a late phase of CHS in TNF-α+/+ (B6129SF2/ J) and Balb/c mice. In the late phase of TMA-induced CHS, the peak of ear swelling responses by single challenge showed at 24 h after challenge, but the peak was observed at 8 h after repeated challenge. In the TNF-α knockout TNF-α-/- (B6;129S-Tnftm1Gk1) mice, the repetition of the TMA challenges enlarged the extent of the late phase of CHS, but less than those in TNF-α+/+mice. Injection of anti-TNF-α antibody into the peritoneal cavity of Balb/c mice significantly decreased the extent of the late phase of CHS. Subcutaneous injection of anti-IgE antibody into Balb/c mice also decreased the extent of the late phase of CHS in dose-dependent manner. Histologi-cally, infiltration of polymorphonuclear leukocytes and eosinophils was more pronounced in repeatedly TMA-challenged TNF-α+/+ and Balb/c mice than in the TNF-α-/- mice and anti-TNF-α or anti-IgE antibodies treated Balb/c mice. These results indicate that mice sensitized by TMA could possibly offer a useful model to study the mechanism of CHS, and TNF-α and IgE may act as potential modulators in the late phase of TMA-induced CHS. Neutralization of TNF-α and IgE by anti-TNF-α or anti-IgE antibodies may provide therapeutic tools for the treatment of TMA-induced CHS.
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참고문헌 (28)
참고문헌 신청
/ / -5 and -6 and tumor necrosis factor-α in normaland asthmatic airways evidence for the human mast cell assource of these cytokines djuka (vicer) : 471 ~ 4 80
/ / Human lung mast cellsand pulmonary macrophages produce tumor necrosis factor-α in sensitized lung tissue after IgE receptor triggering tan (y) : 385 ~ 92
/ / Morphology of delayed-type hypersensitivityreactions in man Quantitative description of theinflammatory response : 111 ~ 30
/ / Morphology of delayedtypehypersensitivity reactions in man : 179 ~ 91
/ 1988 / Evidence that tumornecrosis factor is not constitutively present in vivo theassociation of TNF with freshly isolated monocytes reflects arapid in vitro production :
/ / Human lung mast cellsand pulmonary macrophages produce tumor necrosis factor-α in sensitized lung tissue after IgE receptor triggering tan (y) : 385 ~ 92
/ / Morphology of delayed-type hypersensitivityreactions in man Quantitative description of theinflammatory response : 111 ~ 30
/ / Morphology of delayedtypehypersensitivity reactions in man : 179 ~ 91
/ 1988 / Evidence that tumornecrosis factor is not constitutively present in vivo theassociation of TNF with freshly isolated monocytes reflects arapid in vitro production :
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