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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 492 - 496 (5page)
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Calmegin is a testis-specific molecular chaperon playing a key role in spermatogenesis. However, the transcriptional regulatory mechanisms for calmegin expression are entirely unknown. Herein, we reveal-ed that calmegin is transcriptionally regulated by histone deacetylase (HDAC) and CpG methyltrans-ferase. The cDNA microarray analysis of the human fibrosarcoma cells treated with trichostatin A (TSA) showed an increased level of calmegin mRNA. The the treatment with 5-aza-2-deoxycytidine (5'Aza- dC), implying that epigenetic alterations are in-volved in the transcriptional repression of the gene. Moreover, chromatin immunoprecipitation assay using an anti-acetyl-histone H3 antibody exhibited that the proximal region (-152 ~-31) of the cal-megin promoter is responsible for HDAC-mediated transcriptional repression of the gene. These results demonstrate that calmegin expression is regulated by HDAC and CpG methyltransferase in a coordinative way.
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참고문헌 (16)
참고문헌 신청
/ / Abnormal patterns of DNA methylation inhuman neoplasia potential consequences for tumor progression verti (p) : 383 ~ 90
/ / Histone deacetylase inhibitor activatesthe WAF1/Cip1 gene promoter through the Sp1 sites : 142 ~ 50
/ / Methylated DNAand MeCP2 recruit histone deacetylase to repress transcription 187 (91)
/ / Modulation of p53 andRaf-1 expression in lung cancer cells by depsipeptideFR901228 : 504 ~ 13
/ / Molecular cloning of a novelCa : 7744 ~ 9
/ / Histone deacetylase inhibitor activatesthe WAF1/Cip1 gene promoter through the Sp1 sites : 142 ~ 50
/ / Methylated DNAand MeCP2 recruit histone deacetylase to repress transcription 187 (91)
/ / Modulation of p53 andRaf-1 expression in lung cancer cells by depsipeptideFR901228 : 504 ~ 13
/ / Molecular cloning of a novelCa : 7744 ~ 9
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