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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.1
- 수록면
- 576 - 581 (6page)
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초록· 키워드
오류제보하기
The treatment of cystamine, a transglutaminase (TGase) inhibitor, has beneficial effects in several diseases including CAG-expansion disorders
and cataract. We compared the inhibition
characteristics of cystamine with those of cysteam ine, a reduced form of cystamine expected to be present inside cells. Cystamine is a more potent inhibitor for TGase than cysteamine with different kinetics pattern in a nonreducing
condition. By contrast, under reducing
conditions, the inhibitory effect of cystamine
was comparable with that of cysteamine. However, cystamine inhibited intracellular TGase activity more strongly than cysteamine despite of cytoplasmic reducing environment, suggesting that cystamine itself inhibits in situ TGase activity by forming mixed disulfides.
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참고문헌 (14)
참고문헌 신청
/ / Specificity of guineapig liver transglutaminase for amine substrates : 1756 ~ 65
/ 2000 / Polyamines mysterious modulatorsof cellular functions : 559 ~ 64
/ 2000 / Saransaari P : 509 ~ 26
/ 2002 / Cross linkingof polyglutamine domains catalyzed by tissue transglutaminaseis greatly favored with pathological-length repeats : 53 ~ 67
/ 2002 / GTP is required to stabilize and displaytransamidation activity of transglutaminase 2 : 818 ~ 22
/ 2000 / Polyamines mysterious modulatorsof cellular functions : 559 ~ 64
/ 2000 / Saransaari P : 509 ~ 26
/ 2002 / Cross linkingof polyglutamine domains catalyzed by tissue transglutaminaseis greatly favored with pathological-length repeats : 53 ~ 67
/ 2002 / GTP is required to stabilize and displaytransamidation activity of transglutaminase 2 : 818 ~ 22
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1993 .01
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Effect of Culture Conditions on Cathepsin B Inhibitor Production by aMarine Bacterium, Pseudomonas sp. Strain PB01
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Crystal structure of the complex of DUSP15 and its inhibitor reveals novel inhibitor binding interactions
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2019 .01
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Polyamine과 Polyamine의 생합성에 관련된 효소들의 시금치잎 세포내 분포에 관한 연구
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