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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 310 - 318 (9page)
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초록· 키워드
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Transglutaminase 4 is a member of enzyme family that catalyzes calcium-dependent posttranslational modification of proteins. Although transglutaminase 4 has been shown to have prostate-restricted expression pattern, little is known about the biological function of transglutaminase 4 in human. To gain insight into its role in prostate, we analyzed the expression status of human transglutaminase 4 in benign prostate hyperplasia (BPH) and prostate cancer (PCa). Unexpectedly,RT-PCR and nucleotide sequence analysis showed four alternative splicing variants of transglutaminase 4: transglutaminase 4-L, -M (-M1 and -M2) and -S. The difference between transglutaminase 4-M1 and -M2 is attributed to splicing sites, but not nucleotide size. The deduced amino acid sequences showed that transglutaminase 4-L, -M1 and -M2 have correct open reading frames, whereas transglutaminase 4-S has a truncated reading frame. RT-PCR analysis of clinical samples revealed that transglutaminase 4-M and -S were detected in all tested prostate tissue (80 BPH and 48PCa). Interestingly, transglutaminase 4-L was found in 56% of BPH (45 out of 80) and only in 15% of PCa (7 out of 48). However, transglutaminase 4-L expression did not correlate with serum prostate-specific antigen (PSA) level, prostate volumes or PSA densities. These results will provide a clue to future investigation aiming at delineating physiological and pathological roles of human transglutaminase 4.
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참고문헌 (24)
참고문헌 신청
An G / 1999 / Human prostatespecific transglutaminase gene: promoter cloning, tissuespecific expression, and down-regulation in metastatic prostate cancer / Urology 4 : 1105
Blencowe BJ / 2006 / Alternative splicing: new insights from global analyses / Cell 126 : 37 ~ 47
Carstens RP / 1997 / Alternative splicing of fibroblast growth factor receptor 2 (FGF-R2) in human prostate cancer / Oncogene 15 : 3059 ~ 3065
Chomczynski P / 1987 / Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction / Anal Biochem 162 : 156 ~ 159
Cukierski MA / 1991 / Effects of seminal vesicle and coagulating gland ablation on fertility in rats / Reprod Toxicol 5 : 347 ~ 352
Blencowe BJ / 2006 / Alternative splicing: new insights from global analyses / Cell 126 : 37 ~ 47
Carstens RP / 1997 / Alternative splicing of fibroblast growth factor receptor 2 (FGF-R2) in human prostate cancer / Oncogene 15 : 3059 ~ 3065
Chomczynski P / 1987 / Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction / Anal Biochem 162 : 156 ~ 159
Cukierski MA / 1991 / Effects of seminal vesicle and coagulating gland ablation on fertility in rats / Reprod Toxicol 5 : 347 ~ 352
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