지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 349 - 359 (11page)
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초록· 키워드
오류제보하기
After the first research declaring the generation of human induced pluripotent stem cells (hiPSCs) in 2007, several attempts have been made to model neurodegenerative disease in vitro during the past decade. Parkinson's disease (PD) is the second most common neurodegenerative disorder, which is mainly characterized by motor dysfunction. The formation of unique and filamentous inclusion bodies called Lewy bodies (LBs) is the hallmark of both PD and dementia with LBs. The key pathology in PD is generally considered to be the alpha-synuclein (-syn) accumulation, although it is still controversial whether this protein aggregation is a cause or consequence of neurodegeneration. In the present work, the recently published researches which recapitulated the -syn aggregation phenomena in sporadic and familial PD hiPSC models were reviewed. Furthermore, the advantages and potentials of using patient-derived PD hiPSC with focus on -syn aggregation have been discussed.
목차
등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
Olanow CW / 1999 / Etiology and pathogenesis of Parkinson's disease / Annu Rev Neurosci 22:123~144
Dauer W / 2003 / Parkinson's disease : mechanisms and models / Neuron 39:889~909
Polymeropoulos MH / 1997 / Mutation in the alpha-synuclein gene identified in families with Parkinson's disease / Science 276:2045~2047
Singleton AB / 2003 / alpha-Synuclein locus triplication causes Parkinson's disease / Science 302:841
Chartier-Harlin MC / 2004 / Alpha-synuclein locus duplication as a cause of familial Parkinson's disease / Lancet 364:1167~1169
Dauer W / 2003 / Parkinson's disease : mechanisms and models / Neuron 39:889~909
Polymeropoulos MH / 1997 / Mutation in the alpha-synuclein gene identified in families with Parkinson's disease / Science 276:2045~2047
Singleton AB / 2003 / alpha-Synuclein locus triplication causes Parkinson's disease / Science 302:841
Chartier-Harlin MC / 2004 / Alpha-synuclein locus duplication as a cause of familial Parkinson's disease / Lancet 364:1167~1169
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