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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 793 - 801 (9page)
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초록· 키워드
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The enabled homolog gene (ENAH, hMena) is abundantly expressed in mesangial tissue, and might play an important role in inflammatory processes of IgA nephropathy (IgAN). The present study was conducted to investigate the association between single nucleotide polymorphisms (SNPs) of the ENAH and childhood IgAN. We analyzed 12 SNPs of ENAH in 176 patients with childhood IgAN and 397 healthy controls.
In addition, IgAN patients were dichotomized and compared with respect to several clinical and pathological parameters. Genotyping data showed significant differences between IgAN patients and controls in the frequency of rs2039620, rs12034829, and rs3795443. On comparison of patients with proteinuria to those without proteinuria (≤ or ＞ 4 mg/m2/h), rs12043633 was significantly different between the two groups. With regard to maximum proteinuria (≤ or ＞ 4 mg/m2/h), rs3795443, rs4653643, rs6751, rs10799319, rs7555139, rs576861, and rs487591 showed significant allele frequency differences. For patients with and without gross hematuria, rs4653643, rs6751, rs10799319, rs7555139, rs576861, and rs487591 showed significant allele frequency differences. The rs3795443 was found to be associated with progression of pathological findings. Our results suggest that ENAH polymorphisms are associated with increased susceptibility, development of proteinuria and gross hematuria, and pathological progression of childhood IgAN.
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참고문헌 (23)
참고문헌 신청
Barisoni L / 1999 / The dysregulated podocyte phenotype: a novel concept in the pathogenesis of collapsing idiopathic focal segmental glomerulosclerosis and HIV-associated ne
Bear JE / 2000 / Negative regulation of fibroblast motility by Ena/VASP proteins / Cell 101 : 717 ~ 728
Boeda B / 2007 / Tes, a specific Mena interacting partner, breaks the rules for EVH1 binding / Mol Cell 28 : 1071 ~ 1082
Comerford KM / 2002 / Role of vasodilator-stimulated phosphoprotein in PKA-induced changes in endothelial junctional permeability / FASEB J 16 : 583 ~ 585
Di Modugno F / 2004 / Human Mena protein, a serex-defined antigen overexpressed in breast cancer eliciting both humoral and CD8+ T-cell immune response / Int J Cancer 109 : 9
Bear JE / 2000 / Negative regulation of fibroblast motility by Ena/VASP proteins / Cell 101 : 717 ~ 728
Boeda B / 2007 / Tes, a specific Mena interacting partner, breaks the rules for EVH1 binding / Mol Cell 28 : 1071 ~ 1082
Comerford KM / 2002 / Role of vasodilator-stimulated phosphoprotein in PKA-induced changes in endothelial junctional permeability / FASEB J 16 : 583 ~ 585
Di Modugno F / 2004 / Human Mena protein, a serex-defined antigen overexpressed in breast cancer eliciting both humoral and CD8+ T-cell immune response / Int J Cancer 109 : 9
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