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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 374 - 378 (5page)
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Benzene, a recognized hematotoxicant and carcinogen,can damage the human immune system. We studied the association between single nucleotide polymorphisms (SNPs) in genes involved in innate immunity and benzene hematotoxicity in a cross-sectional study of workers exposed to benzene (250 workers and 140 controls). A total of 1,236 tag SNPs in 149gene regions of six pathways were included in the analysis. Six gene regions were significant for their association with white blood cell (WBC) counts (MBP,VCAM1, ALOX5, MPO, RAC2, and CRP) based on gene-region (P ＜ 0.05) and SNP analyses (FDR ＜0.05). VCAM1 rs3176867, ALOX5 rs7099684, and MPO rs2071409 were the three most significant SNPs.
They showed similar effects on WBC subtypes, especially granulocytes, lymphocytes, and monocytes. A 3-SNP block in ALOXE3 (rs7215658, rs9892383, and rs3027208) showed a global association (omnibus P =0.0008) with WBCs even though the three SNPs were not significant individually. Our study suggests that polymorphisms in innate immunity genes may play a role in benzene-induced hematotoxicity; however, independent replication is necessary.
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참고문헌 (20)
참고문헌 신청
Agency for Toxic Substances / 2007 / Toxicological Profile for Benzene, U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, Atlanta
Basketter DA / 1992 / Further investigation of the prohapten concept: reactions to benzene derivatives in man / Contact Dermatitis 27 : 90 ~ 97
Benjamini Y / 1995 / Controlling the False Discovery Rate: a practical and powerful approach to multiple testing / J. of the Royal Stat. Society B 57 : 289 ~ 300
Chen BE / 2006 / Resampling- based multiple hypothesis testing procedures for genetic case-control association studies / Genet Epidemiol 30 : 495 ~ 507
Excoffier L / 1995 / Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population / Mol Biol Evol 12 : 921 ~ 927
Basketter DA / 1992 / Further investigation of the prohapten concept: reactions to benzene derivatives in man / Contact Dermatitis 27 : 90 ~ 97
Benjamini Y / 1995 / Controlling the False Discovery Rate: a practical and powerful approach to multiple testing / J. of the Royal Stat. Society B 57 : 289 ~ 300
Chen BE / 2006 / Resampling- based multiple hypothesis testing procedures for genetic case-control association studies / Genet Epidemiol 30 : 495 ~ 507
Excoffier L / 1995 / Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population / Mol Biol Evol 12 : 921 ~ 927
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