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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 363 - 368 (6page)
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초록· 키워드
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Dendroaspis natriuretic peptide (DNP), a new member of the natriuretic peptide family, is structurally similar to atrial, brain, and C-type natriuretic peptides.
However, the effects of DNP on the cardiac function are poorly defined. In the present study, we examined the effect of DNP on the cardiac L-type Ca2+ channels in rabbit ventricular myocytes. DNP inhibited the L-type Ca2+current (ICa,L) in a concentration dependent manner with a IC50 of 25.5 nM, which was blocked by an inhibitor of protein kinase G (PKG), KT5823 (1 μM). DNP did not affect the voltage dependence of activation and inactivation of ICa,L. The α1c subunit of cardiac L-type Ca2+channel proteins was phosphorylated by the treatment of DNP (1 μM), which was completely blocked by KT5823 (1 μM). Finally, DNP also caused the shortening of action potential duration in rabbit ventricular tissue by 22.3 ± 4.2% of the control (n = 6), which was completely blocked by KT5823 (1 μM). These results clearly indicate that DNP inhibits the L-type Ca2+ channel activity by phosphorylating the Ca2+ channel protein via PKG activation.
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참고문헌 (14)
참고문헌 신청
Collins E / 2000 / Mechanism of relaxations to dendroaspis natriuretic peptide in canine coronary arteries / J Cardiovasc Pharmacol 35 : 614 ~ 618
Gao T / 1997 / cAMP-dependent regulation of cardiac L-type Ca2+ channels requires membrane targeting of PKA and phosphorylation of channel subunits / Neuron 19 : 185 ~ 196
Goldberg ND / 1975 / Biologic regulation through opposing influences of cyclic GMP and cyclic AMP: the Yin Yang hypothesis / Adv Cyclic Nucleotide Res 5 : 307 ~ 330
Kwak YG / 1995 / KR-30450, a newly synthesized benzopyran derivative, activates the cardiac ATP-sensitive K+ channel / J Pharmacol Exp Ther 275 : 807 ~ 812
Lainchbury JG / 2002 / Actions of a novel synthetic natriuretic peptide on hemodynamics and ventricular function in the dog / Am J Physiol Regul Integr Comp Physiol 282 : R99
Gao T / 1997 / cAMP-dependent regulation of cardiac L-type Ca2+ channels requires membrane targeting of PKA and phosphorylation of channel subunits / Neuron 19 : 185 ~ 196
Goldberg ND / 1975 / Biologic regulation through opposing influences of cyclic GMP and cyclic AMP: the Yin Yang hypothesis / Adv Cyclic Nucleotide Res 5 : 307 ~ 330
Kwak YG / 1995 / KR-30450, a newly synthesized benzopyran derivative, activates the cardiac ATP-sensitive K+ channel / J Pharmacol Exp Ther 275 : 807 ~ 812
Lainchbury JG / 2002 / Actions of a novel synthetic natriuretic peptide on hemodynamics and ventricular function in the dog / Am J Physiol Regul Integr Comp Physiol 282 : R99
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