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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 601 - 610 (10page)
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초록· 키워드
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Activity-dependent dendritic translation in CNS neurons
is important for the synapse-specific provision of
proteins that may be necessary for strengthening of
synaptic connections. A major rate-limiting factor during
protein synthesis is the availability of eukaryotic
translation initiation factor 4E (eIF4E), an mRNA
5'-cap-binding protein. In this study we show by fluorescence
in situ hybridization (FISH) that the mRNA for
eIF4E is present in the dendrites of cultured rat hippocampal
neurons. Under basal culture conditions, 58.7
± 11.6% of the eIF4E mRNA clusters localize with or
immediately adjacent to PSD-95 clusters. Neuronal activation
with KCl (60 mM, 10 min) very significantly increases
the number of eIF4E mRNA clusters in dendrites
by 50.1 and 74.5% at 2 and 6 h after treatment,
respectively. In addition, the proportion of eIF4E
mRNA clusters that localize with PSD-95 increases to
74.4 ± 7.7% and 77.8 ± 7.6% of the eIF4E clusters at
2 and 6 h after KCl treatment, respectively. Our results
demonstrate the presence of eIF4E mRNA in dendrites
and an activity-dependent increase of these clusters at
synaptic sites. This provides a potential mechanism by
which protein translation at synapses may be enhanced
in response to synaptic stimulation.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Anderson P / 2006 / RNA granules / J Cell Biol 172 : 803 ~ 808
Antar LN / 2004 / Metabotropic glutamate receptor activation regulates fragile x mental retardation protein and FMR1 mRNA localization differentially in dendrites and at syna
Asaki C / 2003 / Localization of translational components at the ultramicroscopic level at postsynaptic sites of the rat brain / Brain Res 972 : 168 ~ 176
Ashraf SI / 2006 / Synaptic protein synthesis associated with memory is regulated by the RISC pathway in Drosophila / Cell 124 : 191 ~ 205
Brendza RP / 2000 / A function for kinesin I in the posterior transport of oskar mRNA and Staufen protein / Science 289 : 2120 ~ 2122
Antar LN / 2004 / Metabotropic glutamate receptor activation regulates fragile x mental retardation protein and FMR1 mRNA localization differentially in dendrites and at syna
Asaki C / 2003 / Localization of translational components at the ultramicroscopic level at postsynaptic sites of the rat brain / Brain Res 972 : 168 ~ 176
Ashraf SI / 2006 / Synaptic protein synthesis associated with memory is regulated by the RISC pathway in Drosophila / Cell 124 : 191 ~ 205
Brendza RP / 2000 / A function for kinesin I in the posterior transport of oskar mRNA and Staufen protein / Science 289 : 2120 ~ 2122
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