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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 1 - 9 (9page)
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Proliferation activity has already been established as a prognostic marker or as a marker for anticancer drug sensitivity. In gastric cancer, however, the prognostic significance of proliferation activity is still being debated. Several studies evaluating proliferation activity using Ki-67 have shown controversial results in terms of the relationship between proliferation activity and overall survival (OS) or drug sensitivity in gastric cancer patients. Because cytoskeleton-associated protein 2 (CKAP2) staining has recently been introduced as a marker of proliferation activity, we analyzed 437 gastric cancer tissues through CKAP2 immunohistochemistry, and we evaluated the chromatin CKAP2-positive cell count (CPCC) for proliferation activity. Although the CPCC did not show any significant correlation with OS in the male, female or total number of cases, it did show a significant correlation in the T1 or T2 male patient subgroup, according to log-rank tests (P=0.001) and univariate analysis (P=0.045).
Additionally, multivariate analysis with the Cox proportional hazard regression model showed a significant correlation between the CPCC and OS (P=0.039) for the co-variables of age, gender, T stage, N stage, histology, tumor location, tumor size and adjuvant chemotherapy. In male gastric cancer cell lines, faster-growing cancer cells showed higher sensitivity to cisplatin than slow-growing cells. Thus our study indicates that CPCC-measured proliferation activity demonstrates a significantly worse prognosis in T1 or T2 male gastric cancer patients. The CPCC will help to more precisely classify gastric cancer patients and to select excellent candidates for adjuvant chemotherapy, which in turn will facilitate further clinical chemotherapeutic trials.
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참고문헌 (22)
참고문헌 신청
Aleskandarany MA / 2012 / Prognostic
Carey LA / 2007 / The triple negative paradox : primary tumor chemosensitivity of breast cancer subtypes / Clin Cancer Res 13 : 2329 ~ 2334
Fujii R / 2003 / Relationships between the expression of thymidylate synthase, dihydropyrimidine dehydrogenase, and orotate phosphoribosyltransferase and cell proliferative
Hugh J / 2009 / Breast cancer subtypes and response to docetaxel in node-positive breast cancer : use of an immunohistochemical definition in the BCIRG 001 trial / J Clin On
Kim HS / 2012 / Condensed chromatin staining of CKAP2 as surrogate marker for mitotic figures / J Cancer Res Clin Oncol 138 : 95 ~ 102
Carey LA / 2007 / The triple negative paradox : primary tumor chemosensitivity of breast cancer subtypes / Clin Cancer Res 13 : 2329 ~ 2334
Fujii R / 2003 / Relationships between the expression of thymidylate synthase, dihydropyrimidine dehydrogenase, and orotate phosphoribosyltransferase and cell proliferative
Hugh J / 2009 / Breast cancer subtypes and response to docetaxel in node-positive breast cancer : use of an immunohistochemical definition in the BCIRG 001 trial / J Clin On
Kim HS / 2012 / Condensed chromatin staining of CKAP2 as surrogate marker for mitotic figures / J Cancer Res Clin Oncol 138 : 95 ~ 102
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