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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 47 - 60 (14page)
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Theophylline is commonly used to treat severe asthma and chronic obstructive pulmonary disease (COPD)characterized by non-eosinophilic inflammation.
Acetyl salicylic acid (ASA) is one of the most widely used medications worldwide, but up to 20% of patients with asthma experience aggravated respiratory symptoms after taking ASA. Here we evaluated the adverse effect of ASA on the therapeutic effect of theophylline in mice with non-eosinophilic asthma. A non-eosinophilic asthma mouse model was induced by airway sensitization with lipopolysaccharide-containing allergen and then challenged with allergen alone.
Therapeutic intervention was performed during allergen challenge. Theophylline inhibited lung inflammation partly induced by Th1 immune response. ASA attenuated the beneficial effects of theophylline. However,co-administration of the ASA metabolite salicylic acid (SA) showed no attenuating effect on theophylline treatment. The therapeutic effect of theophylline was associated with increase in cAMP levels, which was blocked by co-treatment of theophylline and ASA. ASA co-treatment also attenuated the anti-inflammatory effects of a specific phosphodiesterase 4 inhibitor.
These results demonstrate that ASA reverses anti-inflammatory effects of theophylline, and that ASA exerts its adverse effects through the inhibition of cAMP production. Our data suggest that ASA reverses lung inflammation in patients taking theophylline, although clinical evidence will be needed.
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참고문헌 (23)
참고문헌 신청
[학술지(정기간행물)
Antithrombotic Trialists' Collaboration / 2002 / Collaborative metaanalysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and s
Au BT / 1998 / Effect of PDE4 inhibitors on zymosan-induced IL-8 release from human neutrophils: synergism with prostanoids and salbutamol / Br J Pharmacol 123 : 1260 ~ 1266
Bateman ED / 2008 / Global strategy for asthma management and prevention: GINA executive summary / Eur Respir J 31 : 143 ~ 178
Busse WW / 2001 / Asthma / N Engl J Med 344 : 350 ~ 362
Antithrombotic Trialists' Collaboration / 2002 / Collaborative metaanalysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and s
Au BT / 1998 / Effect of PDE4 inhibitors on zymosan-induced IL-8 release from human neutrophils: synergism with prostanoids and salbutamol / Br J Pharmacol 123 : 1260 ~ 1266
Bateman ED / 2008 / Global strategy for asthma management and prevention: GINA executive summary / Eur Respir J 31 : 143 ~ 178
Busse WW / 2001 / Asthma / N Engl J Med 344 : 350 ~ 362
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