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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 30 - 37 (8page)
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The cytoplasmic polyadenylation element (CPE)-binding protein (CPEB) binds to CPE containing mRNAs on their 3' untranslated regions (3'UTRs). This RNA binding protein comes out many important tasks, especially in learning and memory, by modifying the translational efficiency of target mRNAs via poly (A)tailing. Overexpressed CPEB has been reported to induce the formation of stress granules (SGs), a sort of RNA granule in mammalian cell lines. RNA granule is considered to be a potentially important factor in learning and memory. However, there is no study about RNA granule in Aplysia. To examine whether an Aplysia CPEB, ApCPEB1, forms RNA granules, we overexpressed ApCPEB1-EGFP in Aplysia sensory neurons.
Consistent with the localization of mammalian CPEB,overexpressed ApCPEB1 formed granular structures,and was colocalized with RNAs and another RNA binding protein, ApCPEB, showing that ApCPEB1 positive granules are RNA-protein complexes. In addition,ApCPEB1 has a high turnover rate in RNA granules which were mobile structures. Thus, our results indicate that overexpressed ApCPEB1 is incorporated into RNA granule which is a dynamic structure in Aplysia sensory neuron. We propose that ApCPEB1granule might modulate translation, as other RNA granules do, and furthermore, influence memory.
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참고문헌 (24)
참고문헌 신청
Anderson P / 2002 / Stressful initiations / J Cell Sci 115 : 3227 ~ 3234
Antar LN / 2005 / Localization of FMRP-associated mRNA granules and requirement of microtubules for activity-dependent trafficking in hippocampal neurons / Genes Brain Behav
Barbee SA / 2006 / Staufen- and FMRP-containing neuronal RNPs are structurally and functionally related to somatic P bodies / Neuron 52 : 997 ~ 1009
Bashkirov VI / 1997 / A mouse cytoplasmic exoribonuclease (mXRN1p) with preference for G4 tetraplex substrates / J Cell Biol 136 : 761 ~ 773
Casadio A / 1999 / A transient, neuron-wide form of CREB-mediated long-term facilitation can be stabilized at specific synapses by local protein synthesis / Cell 99 : 221 ~ 2
Antar LN / 2005 / Localization of FMRP-associated mRNA granules and requirement of microtubules for activity-dependent trafficking in hippocampal neurons / Genes Brain Behav
Barbee SA / 2006 / Staufen- and FMRP-containing neuronal RNPs are structurally and functionally related to somatic P bodies / Neuron 52 : 997 ~ 1009
Bashkirov VI / 1997 / A mouse cytoplasmic exoribonuclease (mXRN1p) with preference for G4 tetraplex substrates / J Cell Biol 136 : 761 ~ 773
Casadio A / 1999 / A transient, neuron-wide form of CREB-mediated long-term facilitation can be stabilized at specific synapses by local protein synthesis / Cell 99 : 221 ~ 2
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