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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 625 - 633 (9page)
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초록· 키워드
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Prostate cancer is a disease involving complicated
multiple-gene alterations. Both NKX3.1 and p53 are
related to prostate cancer and play crucial roles in
prostate cancer progression. However, little is
known about the relationships and interactions
between p53 and NKX3.1 in prostate cancer. We
found that NKX3.1 expression is down-regulated by
over-expression of wild type (wt) p53 in prostate
cancer LNCaP cells. NKX3.1 is down-regulated at
both the mRNA and protein levels by p53 overexpression
due to either transient transfection of
exogenous p53 or induction of endogenous p53. p53
over-expression represses androgen-induced transactivation
of NKX3.1 by inhibiting the promoter of the
androgen acceptor (AR) gene and by blocking
AR-DNA binding activity. In addition, transfection
with the p21 expression vector (pPSA-p21) showed
that p21 does not reduce NKX3.1 expression,
indicating that NKX3.1 expression is not the result of
nonspecific effects of cell growth arrest. Our results
provide biochemical and cellular biologic evidence
that NKX3.1 is down-regulated by p53 over-ex -
pression in prostate cancer cells.
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등록된 정보가 없습니다.
참고문헌 (31)
참고문헌 신청
/ 1988 / The steroid and thyroid hormone receptor superfamily 240 : 889 ~ 95
/ 1992 / A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia 71 : 587 ~ 97
/ 1992 / Definition of a consensus binding site for p53 1 : 45 ~ 9
/ 1992 / Re-pression of the basal c-fos promoter by wild-type p53 20 : 4083 ~ 7
/ 1993 / Induction of Sp1-p53 DNA-binding heterocomplexes during granulocyte/macrophage colony- stimulating factor-dependent proliferation in human erythro-leukemia cell line
/ 1992 / A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia 71 : 587 ~ 97
/ 1992 / Definition of a consensus binding site for p53 1 : 45 ~ 9
/ 1992 / Re-pression of the basal c-fos promoter by wild-type p53 20 : 4083 ~ 7
/ 1993 / Induction of Sp1-p53 DNA-binding heterocomplexes during granulocyte/macrophage colony- stimulating factor-dependent proliferation in human erythro-leukemia cell line
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