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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Prostate cancer has been a critical health problem due to an increase of prostate cancer-related deaths worldwide. Also, a frequent treatment option for prostate cancer is androgen ablation, but this treatment has a limited scope, especially for hormone-refractory cancer. There is an urgent need for the identification of alternative therapeutic strategies for prostate cancer. Previously, over one hundred species of dried-plant methanol extracts were tested for inhibitory effects on proliferation. One of them, Piper longum Linn. was selected based on its potent anti-proliferation effect. The dried root of P. longum Linn. was extracted with 100% methanol for 2-3 days and its extract was fractionated using chloroform. The chloroform layer was then subjected to column chromatography on silica gel, reverse phase-18 (RP-18) and Sephadex LH-20, in turn. Finally, the pure compound was obtained and identified as pipernonaline by NMR spectroscopic and physico-chemical analysis. In this study, anti-proliferation and cell cycle arrest effects of pipernonaline on human prostate cancer PC-3 cells were investigated using the MTT and PI staining, respectively. Our findings suggest that pipernonaline represents a dose-dependent growth inhibition pattern on PC-3 cells and, moreover, its growth inhibition is associated with sub-G1 and G0/G1 cell cycle accumulation in PC-3 cells. Also, these results provide an anticancer candidate for human prostate cancer.
목차
서론
재료 및 방법
결과 및 고찰
감사의 글
References
참고문헌 (19)
참고문헌 신청
1. [학술지(정기간행물)] - Ahn, J. W / 1992 / Piperidine alkaloids from Piper restrofractum fruits / Phytochemistry 31 : 3609 ~ 3612
2. [학술지(정기간행물)] - Bezerra, D. P / 2005 / Antiproliferative effects of two amides, piperine and piplatine, from Piper species / Zeitschrift für Naturforschung 60 : 539 ~ 543
3. [학술지(정기간행물)] - Chaetterjee, A / 1967 / Alkaloids of Piper longum Linn. I. structure and synthesis of piperlongumine and piperlonguminene / Tetrahedron 23 : 1769 ~ 1781
4. [학술지(정기간행물)] - 조효진 / 2009 / Screening and Purification of an Anti-Prostate Cancer Compound, Deoxypodophyllotoxin, from Anthriscus sylvestris Hoffm / 생명과학회지 19 (1) : 9 ~ 14
5. [학술지(정기간행물)] - Duh, C. Y / 1990 / Cytotoxic pyridone alkaloids from the leaves of Piper aborescens / Jornal of Natural Products 53 : 1575 ~ 1577
2. [학술지(정기간행물)] - Bezerra, D. P / 2005 / Antiproliferative effects of two amides, piperine and piplatine, from Piper species / Zeitschrift für Naturforschung 60 : 539 ~ 543
3. [학술지(정기간행물)] - Chaetterjee, A / 1967 / Alkaloids of Piper longum Linn. I. structure and synthesis of piperlongumine and piperlonguminene / Tetrahedron 23 : 1769 ~ 1781
4. [학술지(정기간행물)] - 조효진 / 2009 / Screening and Purification of an Anti-Prostate Cancer Compound, Deoxypodophyllotoxin, from Anthriscus sylvestris Hoffm / 생명과학회지 19 (1) : 9 ~ 14
5. [학술지(정기간행물)] - Duh, C. Y / 1990 / Cytotoxic pyridone alkaloids from the leaves of Piper aborescens / Jornal of Natural Products 53 : 1575 ~ 1577
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UCI(KEPA) : I410-ECN-0101-2009-470-018369309