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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 677 - 685 (9page)
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초록· 키워드
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The early growth response-1 gene (egr-1) encodes a zinc-finger transcription factor Egr-1 and is rapidly inducible by a variety of extracellular stimuli. Anisomycin (ANX), a protein synthesis inhibitor, stimulates mitogen-activated protein kinase (MAPK) pathways and thereby causes a rapid induction of immediate-early response genes. We found that anisomycin treatment of U87MG glioma cells resulted in a marked, time-dependent increase in levels of Egr-1 protein. The results of Northern blot analysis and reporter gene assay of egr-1 gene promoter (Pegr-1) activity indicate that the ANX- induced increase in Egr-1 occurs at the transcrip-tional level. Deletion of the serum response element (SRE) in the 5'-flanking region of egr-1 gene abolished ANX-induced Pegr-1 activity. ANX induced the phosphorylation of the ERK1/2, JNK, and p38 MAPKs in a time-dependent manner and also induced transactivation of Gal4-Elk-1, suggesting that Elk-1 is involved in SRE-mediated egr-1 transcription. Transient transfection of dominant-negative con-structs of MAPK pathways blocked ANX-induced Pegr-1 activity. Furthermore, pretreatment with specific MAPK pathway inhibitors, including the MEK inhibitor U0126, the JNK inhibitor SP600125, inhibited ANX-inducible expression of Egr-1. Taken together, these results suggest that all three MAPK pathways play a crucial role in ANX-induced trans-criptional activation of Pegr-1 through SRE-mediated transactivation of Elk-1.
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참고문헌 (26)
참고문헌 신청
/ / Activation of ternary complex factor Elk-1 by MAP kinases. EMBO J 1993 : 5097 ~ 104
/ / Expression of the c-fos gene and of an fos-related gene is stimulated by platelet-derived growth factor. Science 1984 : 1080 ~ 2
/ / Forsdyke DR. cDNA cloning of mRNAS which increase rapidly in human lymphocytes cultured with concanavalin-A and cycloheximide. Biochem Biophys Res Commun 1985 : 619 ~ 25
/ / Functional serum response elements upstream of the growth factor-inducible gene zif268. Mol Cell Biol 1989 : 4889 ~ 95
/ / Treisman R. Characterization of SAP-1 a protein recruited by serum response factor to the c-fos serum response element. Cell 1992 : 597 ~ 612
/ / Expression of the c-fos gene and of an fos-related gene is stimulated by platelet-derived growth factor. Science 1984 : 1080 ~ 2
/ / Forsdyke DR. cDNA cloning of mRNAS which increase rapidly in human lymphocytes cultured with concanavalin-A and cycloheximide. Biochem Biophys Res Commun 1985 : 619 ~ 25
/ / Functional serum response elements upstream of the growth factor-inducible gene zif268. Mol Cell Biol 1989 : 4889 ~ 95
/ / Treisman R. Characterization of SAP-1 a protein recruited by serum response factor to the c-fos serum response element. Cell 1992 : 597 ~ 612
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