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- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
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- 1 - 14 (14page)
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Epstein–Barr virus (EBV) is a ubiquitous herpesvirus, affecting 490% of the adult population. EBV targets B-lymphocytes and achieves latent infection in a circular episomal form. Different latency patterns are recognized based on latent gene expression pattern. Latent membrane protein-1 (LMP-1) mimics CD40 and, when self-aggregated, provides a proliferation signal via activating the nuclear factor-kappa B, Janus kinase/signal transducer and activator of transcription, phosphoinositide 3-kinase/Akt (PI3K/Akt) and mitogen-activated protein kinase pathways to promote cellular proliferation. LMP-1 also induces BCL-2 to escape from apoptosis and gives a signal for cell cycle progression by enhancing cyclin-dependent kinase 2 and phosphorylation of retinoblastoma (Rb) protein and by inhibiting p16 and p27. LMP-2A blocks the surface immunoglobulin-mediated lytic cycle reactivation. It also activates the Ras/PI3K/Akt pathway and induces Bcl-xL expression to promote B-cell survival. Recent studies have shown that ebv-microRNAs can provide extra signals for cellular proliferation, cell cycle progression and anti-apoptosis. EBV is well known for association with various types of B-lymphocyte, T-lymphocyte, epithelial cell and mesenchymal cell neoplasms. B-cell lymphoproliferative disorders encompass a broad spectrum of diseases, from benign to malignant. Here we review our current understanding of EBV-induced lymphomagenesis and focus on biology, diagnosis and management of EBV-associated B-cell lymphoproliferative disorders.
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참고문헌 (23)
참고문헌 신청
Brinkmann MM / 2006 / Regulation of intracellular signalling by the terminal membrane proteins of members of the Gammaherpesvirinae / J Gen Virol 87 : 1047 ~ 1074
Castillo JJ / 2014 / Viral lymphomagenesis: from pathophysiology to the rationale for novel therapies / Br J Haematol 165 : 300 ~ 315
Dawson CW / 2003 / Epstein-Barr virus latent membrane protein 1(LMP1)activates the phosphatidylinositol 3-kinase/Akt pathway to promote cell survival and induce actin filame
Eliopoulos AG / 2003 / TRAF1 is a critical regulator of JNK signaling by the TRAF-binding domain of the Epstein-Barr virus-encoded latent infection membrane protein 1 but no
Epstein MA / 1964 / Virus particles in cultured lymphoblasts from Burkitt’s lymphoma / Lancet 1 : 702 ~ 703
Castillo JJ / 2014 / Viral lymphomagenesis: from pathophysiology to the rationale for novel therapies / Br J Haematol 165 : 300 ~ 315
Dawson CW / 2003 / Epstein-Barr virus latent membrane protein 1(LMP1)activates the phosphatidylinositol 3-kinase/Akt pathway to promote cell survival and induce actin filame
Eliopoulos AG / 2003 / TRAF1 is a critical regulator of JNK signaling by the TRAF-binding domain of the Epstein-Barr virus-encoded latent infection membrane protein 1 but no
Epstein MA / 1964 / Virus particles in cultured lymphoblasts from Burkitt’s lymphoma / Lancet 1 : 702 ~ 703
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