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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 226 - 231 (6page)
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Epstein Barr virus (EBV)-encoded nuclear antigen-1 (EBNA1) plays a pivotal in an EBV episome replication and persistence.
Despite considerable attempts, there are no EBV drugs or vaccines. We attempted to eradicate EBV episomes by targeting EBNA1 using the transcription activator-like effector nucleases (TALEN) (E1TN). E1TN-mediated transient knockout (KO) of EBNA1 reduced EBNA1 expression, and caused significant loss of EBV genomes and progressive death of EBV-infected cells. Furthermore, when a mixture of EBV-infected Burkitt’s lymphoma (BL) cells and EBV-negative BL cells was targeted by E1TN, EBV-negative cells were counter-selected while most EBV-infected cells died, further substantiating that EBNA1 KO caused selective death of EBV-infected cells. TALEN-mediated transient targeting of EBNA1 attenuated the growth of EBV-infected cells, implicating a possible therapeutic application of E1TN for EBV-associated disorders.
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참고문헌 (21)
참고문헌 신청
Parkin DM / 2006 / The global health burden of infectionassociated cancers in the year 2002 / Int J Cancer 118:3030~3044
Granato M / 2008 / Deletion of Epstein-Barr virus BFLF2 leads to impaired viral DNA packaging, primary egress as well as to the production of defective viral particles / J Virol 82:4042~4051
Adams A / 1975 / Epstein-Barr virus genomes with properties of circular DNA molecules in carrier cells / Proc Natl Acad Sci U S A 72:1477~1481
Raynaud FI / 2005 / In vitro, in vivo pharmacokinetic-pharmacodynamic relationships for the trisubstituted aminopurine cyclin-dependent kinase inhibitors olomoucine, bohemine, CYC202 / Clin Cancer Res 11:4875~4887
Henderson A / 1983 / Chromosome site for Epstein-Barr virus DNA in a Burkitt tumor cell line, in lymphocytes growth-transformed in vitro / Proc Natl Acad Sci U S A 80:1987~1991
Granato M / 2008 / Deletion of Epstein-Barr virus BFLF2 leads to impaired viral DNA packaging, primary egress as well as to the production of defective viral particles / J Virol 82:4042~4051
Adams A / 1975 / Epstein-Barr virus genomes with properties of circular DNA molecules in carrier cells / Proc Natl Acad Sci U S A 72:1477~1481
Raynaud FI / 2005 / In vitro, in vivo pharmacokinetic-pharmacodynamic relationships for the trisubstituted aminopurine cyclin-dependent kinase inhibitors olomoucine, bohemine, CYC202 / Clin Cancer Res 11:4875~4887
Henderson A / 1983 / Chromosome site for Epstein-Barr virus DNA in a Burkitt tumor cell line, in lymphocytes growth-transformed in vitro / Proc Natl Acad Sci U S A 80:1987~1991
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