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- 학술저널
- 저자정보
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- 2015.1
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the milk fat globule-EGF-factor 8 protein (MFG-E8) has been identified in various tissues, where it has an important role in intercellular interactions, cellular migration, and neovascularization. Previous studies showed that MFG-E8 is expressed in different cell types under normal and pathophysiological conditions, but its expression in hematopoietic stem cells (HSCs) during hematopoiesis has not been reported. In the present study, we investigated MFG-E8 expression in multiple hematopoietic tissues at different stages of mouse embryogenesis. Using immunohistochemistry, we showed that MFG-E8 was specifically expressed in CD34+ HSCs at all hematopoietic sites, including the yolk sac, aorta-gonad-mesonephros region, placenta and fetal liver, during embryogenesis. Fluorescence-activated cell sorting and polymerase chain reaction analyses demonstrated that CD34+ cells, purified from the fetal liver, expressed additional HSC markers, c-Kit and Sca-1, and that these CD34+ cells, but not CD34−cells, highly expressed MFG-E8. We also found that MFG-E8 was not expressed in HSCs in adult mouse bone marrow, and that its expression was confined to F4/80+ macrophages. Together, this study demonstrates, for the first time, that MFG-8 is expressed in fetal HSC populations, and that MFG-E8 may have a role in embryonic hematopoiesis.
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참고문헌 (25)
참고문헌 신청
Ait-Oufella H / 2007 / Lactadherin deficiency leads to apoptotic cell accumulation and accelerated atherosclerosis in mice / Circulation 115 : 2168 ~ 2177
Akakura S / 2004 / The opsonin MFG-E8 is a ligand for the alphavbeta5 integrin and triggers DOCK180-dependent Rac1 activation for the phagocytosis of apoptotic cells / Exp Ce
Andersen MH / 1997 / Bovine PAS-6/7binds alpha v beta 5 integrins and anionic phospholipids through two domains / Biochemistry 36 : 5441 ~ 5446
Atabai K / 2005 / Mfge8 is critical for mammary gland remodeling during involution / Mol Biol Cell 16 : 5528 ~ 5537
Atabai K / 2009 / Mfge8diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages / J Clin Invest 119 : 3713 ~ 3722
Akakura S / 2004 / The opsonin MFG-E8 is a ligand for the alphavbeta5 integrin and triggers DOCK180-dependent Rac1 activation for the phagocytosis of apoptotic cells / Exp Ce
Andersen MH / 1997 / Bovine PAS-6/7binds alpha v beta 5 integrins and anionic phospholipids through two domains / Biochemistry 36 : 5441 ~ 5446
Atabai K / 2005 / Mfge8 is critical for mammary gland remodeling during involution / Mol Biol Cell 16 : 5528 ~ 5537
Atabai K / 2009 / Mfge8diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages / J Clin Invest 119 : 3713 ~ 3722
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