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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 417 - 422 (6page)
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Cisplatin is the most effective and widely used chemotherapeutic agent for many types of cancer. Unfortunately, its clinical use is limited by its adverse effects, notably bone marrow suppression leading to abnormal hematopoiesis. We previously revealed that neuropeptide Y (NPY) is responsible for the maintenance of hematopoietic stem cell (HSC) function by protecting the sympathetic nervous system (SNS) fibers survival from chemotherapy-induced bone marrow impairment. Here, we show the NPY-mediated protective effect against bone marrow dysfunction due to cisplatin in an ovarian cancer mouse model. During chemotherapy, NPY mitigates reduction in HSC abundance and destruction of SNS fibers in the bone marrow without blocking the anticancer efficacy of cisplatin, and it results in the restoration of blood cells and amelioration of sensory neuropathy. Therefore, these results suggest that NPY can be used as a potentially effective agent to improve bone marrow dysfunction during cisplatinbased cancer therapy.
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참고문헌 (24)
참고문헌 신청
Armstrong DK / 2007 / A phase I study of paclitaxel, topotecan, cisplatin and filgrastim in patients with newly diagnosed advanced ovarian epithelial malignancies: a Gynecolo
Banfi A / 2001 / High-dose chemotherapy shows a dose-dependent toxicity to bone marrow osteoprogenitors: a mechanism for post-bone marrow transplantation osteopenia / Cancer
Blanchard EM / 2012 / Cisplatin and solid tumours: still working, after all these years / J Solid Tumors 2 : 26 ~ 33
Butler JM / 2010 / Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells / Cell Stem Cell 6 : 251 ~ 264
Can A / 2008 / Haematopoietic stem cells niches: Interrelations between structure and function / Transfus Apher Sci 38 : 261 ~ 268
Banfi A / 2001 / High-dose chemotherapy shows a dose-dependent toxicity to bone marrow osteoprogenitors: a mechanism for post-bone marrow transplantation osteopenia / Cancer
Blanchard EM / 2012 / Cisplatin and solid tumours: still working, after all these years / J Solid Tumors 2 : 26 ~ 33
Butler JM / 2010 / Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells / Cell Stem Cell 6 : 251 ~ 264
Can A / 2008 / Haematopoietic stem cells niches: Interrelations between structure and function / Transfus Apher Sci 38 : 261 ~ 268
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