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- 학술저널
- 저자정보
- 발행연도
- 2017.1
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Non-muscle invasive bladder cancer (NMIBC) patients frequently fail to respond to treatment and experience disease progression because of their clinical and biological diversity. In this study, we identify a prognostic molecular signature for predicting the heterogeneity of NMIBC by using an integrative analysis of copy number and gene expression data. We analyzed the copy number and gene expression profiles of 404 patients with bladder cancer obtained from The Cancer Genome Atlas (TCGA) consortium. Of the 14 molecules with significant copy number alterations that were previously reported, 13 were significantly correlated with copy number and expression changes. Prognostic gene sets based on the 13 genes were developed, and their prognostic values were verified in three independent patient cohorts (n=501). Among them, a signature of CCNE1 and its coexpressed genes was significantly associated with disease progression and validated in the independent cohorts. The CCNE1 signature was an independent risk factor based on the result of a multivariate analysis (hazard ratio=6.849, 95% confidence interval=1.613–29.092, P=0.009). Finally, gene network and upstream regulator analyses revealed that NMIBC progression is potentially mediated by CCND1-CCNE1-SP1 pathways. The prognostic molecular signature defined by copy number and expression changes of CCNE1 suggests a novel diagnostic tool for predicting the likelihood of NMIBC progression.
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참고문헌 (24)
참고문헌 신청
Babjuk M / 2013 / EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder : update 2013 / Eur Urol 64 : 639 ~ 653
Beishline K / 2015 / Sp1 and the 'hallmarks of cancer’ / FEBS J 282 : 224 ~ 258
Cancer Genome Atlas Research N / 2014 / Comprehensive molecular characterization of urothelial bladder carcinoma / Nature 507 : 315 ~ 322
Chatterjee SJ / 2004 / Combined effects of p53, p21, and pRb
Cheng L / 2012 / Identification of genes with a correlation between copy number and expression in gastric cancer / BMC Med Genomics 5 : 14 ~
Beishline K / 2015 / Sp1 and the 'hallmarks of cancer’ / FEBS J 282 : 224 ~ 258
Cancer Genome Atlas Research N / 2014 / Comprehensive molecular characterization of urothelial bladder carcinoma / Nature 507 : 315 ~ 322
Chatterjee SJ / 2004 / Combined effects of p53, p21, and pRb
Cheng L / 2012 / Identification of genes with a correlation between copy number and expression in gastric cancer / BMC Med Genomics 5 : 14 ~
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