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Activation of Innate Immune System During Viral Infection
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Activation of Innate Immune System During Viral Infection : Role of Pattern-recognition Receptors (PRRs) in Viral Infection

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Type
Academic journal
Author
Eun Jung Jun (울산대학교) Yoo Kyum Kim (울산대학교)
Journal
The Korean Society For Microblology JOURNAL OF BACTERIOLOGY AND VIROLOGY Vol.39 No.3 KCI Accredited Journals SCOPUS
Published
2009.9
Pages
145 - 157 (13page)

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Activation of Innate Immune System During Viral Infection
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Innate immunity and adaptive immunity are two major immune responses against pathogens. Innate immunity is responsible for the immediate immune response to pathogens. Pattern-recognition receptors (PRRs) play an important role in innate immune response. PRRs recognize regular patterns of molecule structure known as pathogen-associated molecular patterns (PAMPs). Among the PRRs, Toll-like receptors (TLRs), RIG-I-like receptors (RLRs), and DNA-dependent activator of interferon regulatory factors (DAI) display key roles in response to viral infections. This article reviews how viral infections activate PRR-PAMP signal pathways and how viruses evade immune responses elicited by PRR signal pathways.
#Innate immunity #Viral infection #Toll-like receptor #RIG-I-like receptor #PAMP

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