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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
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- 2006.1
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- 1 - 10 (10page)
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The Wnt signaling pathway is conserved in various species from worms to mammals, and plays im-portant roles in cellular proliferation, differentiation, and migration. Wnt stabilizes cytoplasmic β-catenin and then the accumulated β-catenin is translocated into the nucleus, where it activates the transcriptional factor T-cell factor (Tcf)/lymphoid enhancer factor (Lef), and thereby stimulates the expression of genes including c-myc, c-jun, fra-1, and cyclin D1. Tight regulation of this response involves post-trans-lational modifications of the components of the Wnt signaling pathway. Phosphorylation, ubiquitination, and sumoylation have been shown to affect the half-life of β-catenin and the transcriptional activity of Tcf/Lef. The precise spatio-temporal patterns of these multiple modifications determine the driving force of various cellular responses.
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참고문헌 (27)
참고문헌 신청
[학술지(정기간
/ 1998 / Axin, a negative regulator of the Wnt signaling pathway forms a complex with GSK-3 and -catenin and promotes GSK-3-dependent phosphorylation of -catenin 17 : 1371 ~
/ 1998 / Functional interaction of an Axin homolog, conductin, with -catenin, APC, and GSK3. 280 : 596 ~ 9
/ 1998 / The ubiquitin-proteasome pathway: on pro-tein death and cell life. 17 : 7151 ~ 60
/ 1999 / Regulation of Wnt signaling by protein-protein interaction and post-translational modifications 9Kerridge S The C-terminal domain of armadillo binds to hypophospho
/ 1998 / Axin, a negative regulator of the Wnt signaling pathway forms a complex with GSK-3 and -catenin and promotes GSK-3-dependent phosphorylation of -catenin 17 : 1371 ~
/ 1998 / Functional interaction of an Axin homolog, conductin, with -catenin, APC, and GSK3. 280 : 596 ~ 9
/ 1998 / The ubiquitin-proteasome pathway: on pro-tein death and cell life. 17 : 7151 ~ 60
/ 1999 / Regulation of Wnt signaling by protein-protein interaction and post-translational modifications 9Kerridge S The C-terminal domain of armadillo binds to hypophospho
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Wnt/β-catenin 신호를 조절하는 인산화 효소
생명과학회지
2013 .07
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Silybin Synergizes with Wnt3a in Activation of the Wnt/β-catenin Signaling Pathway through Stabilization of Intracellular β-Catenin Protein
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Wnt5a stimulates chemotactic migration and chemokine production in human neutrophils
Experimental and Molecular Medicine
2013 .01
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Transcriptional Regulation and Apoptosis Induction by Tcf/$\beta$-Catenin Complex in Various T-Cells
Korean journal of biological sciences
2000 .01
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Bryostatin-1에 의한 Wnt/β-Catenin 신호전달체계 저해효과
한국미생물·생명공학회지
2014 .01
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참그물 바탕말 추출물에 의한 Wnt/β-Catenin 신호전달체계 저해
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2006 .12
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$\beta$-catenin에 의한 신호전달과 그 역할 ($\beta$-catenin은 세포의 감초인가\ulcorner)
한국동물학회 뉴스레터
2001 .01
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Complex Interplay between the RUNX Transcription Factors and Wnt/β-Catenin Pathway in Cancer: A Tango in the Night
Molecules and Cells
2020 .01
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Hypermethylation of Frizzled1 is associated with Wnt/β-catenin signaling inactivation in mesenchymal stem cells of patients with steroid-associated osteonecrosis
Experimental and Molecular Medicine
2019 .01
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Wnt/β-catenin interacts with the FGF pathway to promote proliferation and regenerative cell proliferation in the zebrafish lateral line neuromast
Experimental and Molecular Medicine
2019 .01
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The Wnt/β-catenin signaling pathway regulates the development of airway remodeling in patients with asthma
Experimental and Molecular Medicine
2015 .01
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대장상피세포 속 Wnt 신호 경로에 대한 C. difficile 톡신A의 영향
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2018 .09
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Association of β-Catenin with Fat Accumulation in 3T3-L1 Adipocytes and Human Population
생명과학회지
2011 .09
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Wnt7b is Upregulated in Macrophages during Thymic Regeneration and Negatively Regulated by RANKL
생명과학회지
2007 .07
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Effect of Histone Deacetylase Inhibitors on Differentiation of Human Bone Marrow-derived Stem Cells Into Neuron-like Cells
조선자연과학논문집
2019 .01
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The Effects of Wnt Signaling on Neural Crest Lineage Segregation and Specification
생명과학회지
2009 .10
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miR-148a is a downstream effector of X-box-binding protein 1 that silences Wnt10b during adipogenesis of 3T3-L1 cells
Experimental and Molecular Medicine
2016 .01
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Euodia sutchuenensis Dode extract stimulates osteoblast differentiation via Wnt/β-catenin pathway activation
Experimental and Molecular Medicine
2015 .01
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Dual modulation of human hepatic zonation via canonical and non-canonical Wnt pathways
Experimental and Molecular Medicine
2017 .01
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