지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
오류제보하기
Neural crest는 신경계의 발생과정에서 생긴 특정화된 외배엽으로서 말초신경계(peripheral nervous system)의 모든 sensory cells과 peripheral cells, unipolar spinal ganglion cell, cranial sensory ganglia, peripheral nerve의 neurolemmal sheath cells, ganglia의 capsule cells, sympathetic ganglia, chromaffin cells, pigment cell 등의 자율신 경계의 대부분의 세포로 분화 한다. 최근pluripotetic neural crest cells의 운명이 이미 제한되어 있으며, 이러한 fate-restricted crest cells이 neural tube에서 emigration된다고 보고된바 있다. 또한 본 연구자는 Wnt와 Wnt의 antagonist가 neural crest cell의 specification이 일어나는 시기에 발현하여, neural crest cell의 segregation과 differentiation에 직접적으로 관여함을 밝혔다. 이를 보다 명확히 규명하기 위해, 본 연구에서는 neural tube에 Wnt-3a expressing cell의 grafting 혹은 dominant negative GSK construct의 electroporation을 통해 Wnt signaling을 modulation 하여 downstream mediator를 조사하였다. Wnt signaling의 stimulation은 neural crest cell의 melanoblast 로의 commitment를 유도하였으며, 이와 더불어 cadherin 7과 slug의 발현을 조절함을 확인하였다.
목차
Introduction
Materials and Methods
Results
Discussion
Acknowledgements
References
초록
참고문헌 (23)
참고문헌 신청
1. [학술지(정기간행물)] - Barrio, M. G / 2002 / Overexpression of Snail family members highlights their ability to promote chick neural crest formation / Development 129 : 1583 ~ 1593
2. [학술지(정기간행물)] - Bienz, M / 1998 / TCF: transcriptional activator or repressor? / Curr. Opin. Cell Biol. 10 : 366 ~ 372
3. [학술지(정기간행물)] - Bradley, R. S. / 1993 / Expression of Wnt-1 in PC12 cells results in modulation of plakoglobin and E-cadherin and increased cellular adhesion / J. Cell Biol. 123 : 1857 ~ 1865
4. [학술지(정기간행물)] - Chapman, S. C. / 2001 / Improved method for chick whole-embryo culture using a filter paper carrier / Dev. Dyn. 220 : 284 ~ 289
5. [학술지(정기간행물)] - Clevers, H / 1997 / TCF/LEF factors earn their wings / Trends Genet. 13 : 485 ~ 489
2. [학술지(정기간행물)] - Bienz, M / 1998 / TCF: transcriptional activator or repressor? / Curr. Opin. Cell Biol. 10 : 366 ~ 372
3. [학술지(정기간행물)] - Bradley, R. S. / 1993 / Expression of Wnt-1 in PC12 cells results in modulation of plakoglobin and E-cadherin and increased cellular adhesion / J. Cell Biol. 123 : 1857 ~ 1865
4. [학술지(정기간행물)] - Chapman, S. C. / 2001 / Improved method for chick whole-embryo culture using a filter paper carrier / Dev. Dyn. 220 : 284 ~ 289
5. [학술지(정기간행물)] - Clevers, H / 1997 / TCF/LEF factors earn their wings / Trends Genet. 13 : 485 ~ 489
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UCI(KEPA) : I410-ECN-0101-2009-470-019015933