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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 71 - 76 (6page)
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Background and Objectives: The role of thyroid-stimulating hormone (TSH) signaling on osteoblastic differentiation is still undetermined. The aim of this study was to investigate the effects of 5-aza-2'-deoxycytidine (5-azacytidine) on TSH-mediated regulations of osteoblasts. Materials and Methods: MG63, a human osteoblastic cell-line, was treated with 5-azacytidine before inducing osteogenic differentiation using osteogenic medium (OM) containing L-ascorbic acid and β-glyceophosphate. Bovine TSH or monoclonal TSH receptor stimulating antibody (TSAb) was treated. Quantitative real-time PCR analyses or measurement of alkaline phosphatase activities were performed for evaluating osteoblastic differentiation. Results: Studies for osteogenic-related genes or alkaline phosphatase activity demonstrated that treatment of TSH or TSAb alone had no effects on osteoblastic differentiation in MG63 cells. However, treatment of 5-azacytidine, per se, significantly increased osteoblastic differentiation and combination treatment of 5-azacytidine and TSH or TSAb in the condition of OM showed further significant increase of osteoblastic differentiation. Conclusion: Stimulating TSH signaling has little effects on osteoblastic differentiation in vitro. However, in the condition of epigenetic modification using inhibitor of DNA methylation, TSH signaling positively affects osteoblastic differentiation in human osteoblasts.
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참고문헌 (18)
참고문헌 신청
Abe E / 2003 / TSH is a negative regulator of skeletal remodeling / Cell 115 (2) : 151 ~ 162
Baliram R / 2011 / Thyroid-stimulating hormone induces a Wnt-dependent, feed-forward loop for osteoblastogenesis in embryonic stem cell cultures / Proc Natl Acad Sci U S A 1
Baran DT / 1994 / Thyroid hormone and bone mass: the clinician's dilemma / Thyroid 4 (2) : 143 ~ 144
Bassett JH / 2003 / The molecular actions of thyroid hormone in bone / Trends Endocrinol Metab 14 (8) : 356 ~ 364
Blum MR / 2015 / Subclinical thyroid dysfunction and fracture risk: a meta-analysis / JAMA 313 (20) : 2055 ~ 2065
Baliram R / 2011 / Thyroid-stimulating hormone induces a Wnt-dependent, feed-forward loop for osteoblastogenesis in embryonic stem cell cultures / Proc Natl Acad Sci U S A 1
Baran DT / 1994 / Thyroid hormone and bone mass: the clinician's dilemma / Thyroid 4 (2) : 143 ~ 144
Bassett JH / 2003 / The molecular actions of thyroid hormone in bone / Trends Endocrinol Metab 14 (8) : 356 ~ 364
Blum MR / 2015 / Subclinical thyroid dysfunction and fracture risk: a meta-analysis / JAMA 313 (20) : 2055 ~ 2065
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