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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한치주과학회 Journal of Periodontal & Implant Science Journal of Periodontal & Implant Science 제47권 제5호
- 발행연도
- 2017.1
- 수록면
- 273 - 291 (19page)
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Purpose: Although static magnetic fields (SMFs) have been used in dental prostheses and osseointegrated implants, their biological effects on osteoblastic and cementoblastic differentiation in cells involved in periodontal regeneration remain unknown. This study was undertaken to investigate the effects of SMFs (15 mT) on the osteoblastic and cementoblastic differentiation of human osteoblasts, periodontal ligament cells (PDLCs), and cementoblasts, and to explore the possible mechanisms underlying these effects.
Methods: Differentiation was evaluated by measuring alkaline phosphatase (ALP) activity, mineralized nodule formation based on Alizarin red staining, calcium content, and the expression of marker mRNAs assessed by reverse transcription polymerase chain reaction (RT-PCR). Signaling pathways were analyzed by western blotting and immunocytochemistry.
Results: The activities of the early marker ALP and the late markers matrix mineralization and calcium content, as well as osteoblast- and cementoblast-specific gene expression in osteoblasts, PDLCs, and cementoblasts were enhanced. SMFs upregulated the expression of Wnt proteins, and increased the phosphorylation of glycogen synthase kinase-3β (GSK-3β) and total β-catenin protein expression. Furthermore, p38 and c-Jun N-terminal kinase (JNK) mitogen-activated protein kinase (MAPK), and nuclear factor-κB (NF-κB) pathways were activated.
Conclusions: SMF treatment enhanced osteoblastic and/or cementoblastic differentiation in osteoblasts, cementoblasts, and PDLCs. These findings provide a molecular basis for the beneficial osteogenic and/or cementogenic effect of SMFs, which could have potential in stimulating bone or cementum formation during bone regeneration and in patients with periodontal disease.
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참고문헌 (23)
참고문헌 신청
Aksu AE / 2014 / Intraoral use of extraoral implants for oral rehabilitation of a pediatric patient after resection of ewing sarcoma of the mandible and reconstruction with i
Bartold PM / 2006 / Molecular and cell biology of healthy and diseased periodontal tissues / Periodontol 2000 40 : 29 ~ 49
Chiu KH / 2007 / Static magnetic fields promote osteoblastlike cells differentiation via increasing the membrane rigidity / Ann Biomed Eng 35 : 1932 ~ 1939
Chung JH / 2014 / Deferoxamine promotes osteoblastic differentiation in human periodontal ligament cells via the nuclear factor erythroid 2-related factormediated antioxidan
Cook JJ / 2015 / Healing in the new millennium : bone stimulators : an overview of where we've been and where we may be heading / Clin Podiatr Med Surg 32 : 45 ~ 59
Bartold PM / 2006 / Molecular and cell biology of healthy and diseased periodontal tissues / Periodontol 2000 40 : 29 ~ 49
Chiu KH / 2007 / Static magnetic fields promote osteoblastlike cells differentiation via increasing the membrane rigidity / Ann Biomed Eng 35 : 1932 ~ 1939
Chung JH / 2014 / Deferoxamine promotes osteoblastic differentiation in human periodontal ligament cells via the nuclear factor erythroid 2-related factormediated antioxidan
Cook JJ / 2015 / Healing in the new millennium : bone stimulators : an overview of where we've been and where we may be heading / Clin Podiatr Med Surg 32 : 45 ~ 59
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