지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Background : The hospitalized patients requiring parenteral nutrition (PN) often need to receive intravenous medications as well, as noted in some cases. The Y-site administration is occasionally necessary, but some physicochemical incompatibilities can occur between the medications and PN. The absence of drug compatibility information with 3-in-1 parenteral nutrition admixture (PNA) has been problematic in this case. The infusion of a precipitate or destabilized emulsion can be harmful for the patients. Therefore, the aim of this study was to evaluate the physical compatibility of 2 selected drugs during a simulated Y-site injection and additive condition into a 3-in-1 PNA. Methods : 3-in-1 PNA (OMAFONE Inj 986 mL) were tested with two drugs (diltiazem, vasopressin). PNAs and drugs were mixed in 1:1(v/v) proportions and the compatibility was assessed at the time of mixing and after 1, 24, 48 and 72 hours. Chiefly, the assessment of potential precipitation and the emulsion stability was performed by a subvisual particle counting an, through visual examinations and a measurement of globule size distribution. Results : In all samples we did not observe changes on the visual examinations. It is noted that the oil droplet mean size changes over 1.5 μm are to exceed 2% in the Y-site samples of diltiazem and vasopressin within 24 hours. In particular, these samples of vasopressin did not disappear until after a 72 hours timeframe. However, the globule size distribution via a dynamic light scattering are maintained at 200-300 nm during the experimental period. Conclusions : The present study experiment noted the compatibility of 1 commercially available PNA and 2 medications. The extrapolation of compatibility data based on conditions applicable for other products is not recommended. It is noted that a different outcome can also be a result of differences in the methodology or interpretation of the results. Finally, we recommend that a filter is concerned primarily with the protection of patients from the effects of an infusion of particulates and chemical precipitates. The appropriate use of this complex therapy is able to maximize the clinical benefit while minimizing the potential risks for adverse events.
목차
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참고문헌 (23)
참고문헌 신청
McClave SA / 2009 / Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient: Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (A.S.P. E.N.) / JPEN J Parenter Enteral Nutr 33:277~316
Heyland DK / 1998 / Total parenteral nutrition in the critically ill patient: a meta-analysis / JAMA 280:2013~2019
Ziegler TR / 2009 / Parenteral nutrition in the critically ill patient / N Engl J Med 361:1088~1097
Alberda C / 2009 / The relationship between nutritional intake and clinical outcomes in critically ill patients: results of an international multicenter observational study / Intensive Care Med 35:1728~1737
Tucker A / 2015 / Standards of practice for nutrition support pharmacists task force; American society for parenteral and enteral nutrition. American society for parenteral and enteral nutrition (A.S.P.E.N.) standards of practice for nutrition support pharmacists / Nutr Clin Pract 30(1):139~146
Heyland DK / 1998 / Total parenteral nutrition in the critically ill patient: a meta-analysis / JAMA 280:2013~2019
Ziegler TR / 2009 / Parenteral nutrition in the critically ill patient / N Engl J Med 361:1088~1097
Alberda C / 2009 / The relationship between nutritional intake and clinical outcomes in critically ill patients: results of an international multicenter observational study / Intensive Care Med 35:1728~1737
Tucker A / 2015 / Standards of practice for nutrition support pharmacists task force; American society for parenteral and enteral nutrition. American society for parenteral and enteral nutrition (A.S.P.E.N.) standards of practice for nutrition support pharmacists / Nutr Clin Pract 30(1):139~146
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