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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 141 - 147 (7page)
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Background: Pulmonary carcinoid tumors consisting of typical carcinoid tumors (TC) and atypical carcinoid tumors (AC) are rare, accounting for 2-5% of all lung tumors. TC is considered a low-grade tumor with a rate of distant metastasis up to 12%. In contrast, ACs are more aggressive tumors, displaying a metastatic rate up to 70%. Surgery is the treatment of choice; however, the current treatment outcomes of metastatic lung carcinoids are discouraging. This study aimed to investigate the EGFR mutation using the PNA-mediated clamping method and to provide basic data for using EGFR-TK1 and its clinical implications. Materials and Methods: A total of 14 cases that underwent surgery were diagnosed as carcinoid tumors and pathologically classified as TC and AC. The paraffin-embedded tissues were analyzed for EGFR mutations using the PNA-mediated PCR clamping technique. The mutant type was noted in the cases with a △Ct greater than 2.0. Result: Of 14 cases, eight were AC and six cases were TC. No known EGFR mutation was detected with a △Ct less than 2.0. Conclusion: The EGFR genotype determined using the PNA-mediated PCR clamping method was wild-type in all pulmonary carcinoid tumors. Therefore, the application of EGFR-TK1 is limited in pulmonary carcinoid tumors.
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참고문헌 (23)
참고문헌 신청
Cardillo G / 2004 / Bronchial carcinoid tumors : nodal status and long-term survival after resection / Ann Thorac Surg 77:1781~1785
Travis WD / 1998 / Reproducibility of neuroendocrine lung tumor classification / Hum Pathol 29:272~279
Kelly K / 2008 / Biological agents in non-small cell lung cancer : a review of recent advances and clinical results with a focus on epidermal growth factor receptor and vascular endothelial growth factor / J Thorac Oncol 3:664~673
Lynch TJ / 2004 / Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib / N Engl J Med 350:2129~2139
Paez JG / 2004 / EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy / Science 304:1497~1500
Travis WD / 1998 / Reproducibility of neuroendocrine lung tumor classification / Hum Pathol 29:272~279
Kelly K / 2008 / Biological agents in non-small cell lung cancer : a review of recent advances and clinical results with a focus on epidermal growth factor receptor and vascular endothelial growth factor / J Thorac Oncol 3:664~673
Lynch TJ / 2004 / Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib / N Engl J Med 350:2129~2139
Paez JG / 2004 / EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy / Science 304:1497~1500
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