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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Background: The causal networks among genes that are commonly expressed in osteoblasts and during bone metastasis (BM) of breast cancer (BC) are not well understood. Here, we developed a machine learning method to obtain a plausible causal network of genes that are commonly expressed during BM and in osteoblasts in BC. Methods: We selected BC genes that are commonly expressed during BM and in osteoblasts from the Gene Expression Omnibus database. Bayesian Network Inference with Java Objects (Banjo) was used to obtain the Bayesian network. Genes registered as BC related genes were included as candidate genes in the implementation of Banjo. Next, we obtained the Bayesian structure and assessed the prediction rate for BM, conditional independence among nodes, and causality among nodes. Furthermore, we reported the maximum relative risks (RRs) of combined gene expression of the genes in the model. Results: We mechanistically identified 33 significantly related and plausibly involved genes in the development of BC BM. Further model evaluations showed that 16 genes were enough for a model to be statistically significant in terms of maximum likelihood of the causal Bayesian networks (CBNs) and for correct prediction of BM of BC. Maximum RRs of combined gene expression patterns showed that the expression levels of UBIAD1, HEBP1, BTNL8, TSPO, PSAT1, and ZFP36L2 significantly affected development of BM from BC. Conclusions: The CBN structure can be used as a reasonable inference network for accurately predicting BM in BC.
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참고문헌 (53)
참고문헌 신청
Randall RL / 2014 / A promise to our patients with metastatic bone disease / Ann Surg Oncol 21:4049~4050
Lipton A / 2000 / Pamidronate prevents skeletal complications and is effective palliative treatment in women with breast carcinoma and osteolytic bone metastases: long term follow-up of two randomized, placebo-controlled trials / Cancer 88:1082~1090
Mundy GR / 2002 / Metastasis to bone: causes, consequences and therapeutic opportunities / Nat Rev Cancer 2:584~593
Roodman GD / 2004 / Mechanisms of bone metastasis / N Engl J Med 350:1655~1664
Hernandez RK / 2015 / Prevalence of bone metastases and bone-targeting agent use among solid tumor patients in the United States / Clin Epidemiol 7:335~345
Lipton A / 2000 / Pamidronate prevents skeletal complications and is effective palliative treatment in women with breast carcinoma and osteolytic bone metastases: long term follow-up of two randomized, placebo-controlled trials / Cancer 88:1082~1090
Mundy GR / 2002 / Metastasis to bone: causes, consequences and therapeutic opportunities / Nat Rev Cancer 2:584~593
Roodman GD / 2004 / Mechanisms of bone metastasis / N Engl J Med 350:1655~1664
Hernandez RK / 2015 / Prevalence of bone metastases and bone-targeting agent use among solid tumor patients in the United States / Clin Epidemiol 7:335~345
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