지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 32 - 37 (6page)
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초록· 키워드
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Purpose : Perinatal asphyxia is an important cause of neonatal mortality and subsequent
lifelong neurodevelopmental handicaps. Although many treatment strategies have
been tested, there is currently no clinically effective treatment to prevent or reduce the
harmful effects of hypoxia and ischemia in humans. In the clinical setting, maternal hyperthermia
induces adverse effects on the neonatal brain, but recent studies have shown that
hyperthermic pretreatment (PT) plays some role in hypoxic-ischemic (HI) injuries of the
developing brain. The present study investigated the effect of hyperthermic PT on HI
brain injuries in newborn rats.
Methods : HI was produced in 7-day-old neonatal rats by unilateral common carotid
artery ligation, followed by hypoxia with 8% oxygen at 38℃ for 2 hours. Twenty-four
hours before HI, one-half of the pups were exposed to a 40℃ environment for 2 hours.
The severity of the brain injury was assessed 7 days after the HI.
Results : Hyperthermic PT reduced the gross and histopathologic findings of brain injury
from 64.7 to 31.2% (P<0.05). There were no differences in location and severity of
injury between the pretreated and control brains.
Conclusion : These findings indicate that hyperthermic PT provides neuroprotective
benefits on HI in the developing brain. Also, these findings suggest maternal hyperthermia
may have protective effect on perinatal HI brain injuries.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Adamson S
Amorim P / 1999 / Effect of small changes in temperature on CA1 pyramidal cells from rat hippocampal slices during hypoxia: implications about the mechanism of hypothermic p
Bona E / 1998 / Protective effects of moderate hypothermia after neonatal hypoxia-ischemia: shortand long-term outcome / Pediatr Res 43 : 738 ~ 745
Cantagrel S / 2003 / Hypoxic preconditioning reduces apoptosis in a rat model of immature brain hypoxia-ischaemia / Neurosci Lett 347 : 106 ~ 110
Cataltepe O / 1995 / Effect of status epilepticus on hypoxic-ischemic brain damage in the immature rat / Pediatr Res 38 : 251 ~ 257
Amorim P / 1999 / Effect of small changes in temperature on CA1 pyramidal cells from rat hippocampal slices during hypoxia: implications about the mechanism of hypothermic p
Bona E / 1998 / Protective effects of moderate hypothermia after neonatal hypoxia-ischemia: shortand long-term outcome / Pediatr Res 43 : 738 ~ 745
Cantagrel S / 2003 / Hypoxic preconditioning reduces apoptosis in a rat model of immature brain hypoxia-ischaemia / Neurosci Lett 347 : 106 ~ 110
Cataltepe O / 1995 / Effect of status epilepticus on hypoxic-ischemic brain damage in the immature rat / Pediatr Res 38 : 251 ~ 257
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