지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 63 - 70 (8page)
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초록· 키워드
오류제보하기
Nitrogen-containing bisphosphonates are potent inhibitors of osteoclastic activity that are now widely used for preventing the bone loss associated with osteoporosis, Paget's disease, hypercalcemia and metastatic bone disease. The clinical efficacy of bisphosphonate is determined by the bone mineral binding affinity and the extent of inhibition of farnesyl pyrophosphate synthase, a target enzyme of bisphosphonate. Each bisphosphonate has unique structural properties. The structure-function profile of individual bisphosphonates is determined by R1 and R2 side chains. Bone binding affinity is enhanced when R1 side chain is a hydroxyl group. The R2 side chains determines the antiresorptive potency of the bisphosphonate but has some effect on binding. The nitrogen moiety within the R2 side chain potentiate the FPPS inhibitory action of bisphosphonate. Structural differences among bisphosphonates explain the observed differences in mineral binding affinity and antiresorptive potency and may in turn account for some of clinical differences that have been seen in potency, disease-specific efficacy, speed of onset, offset of action and antifracture efficacy in various clinical trials.
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등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Black DM / 2006 / Effects of continuing or stopping alendronate after 5 years treatment. The Fracture Intervention Trial Long-term Extension (FLEX): A randomized trial / JAM
Black DM / 2007 / Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis / N Engl J Med 356 : 1809 ~ 1822
Boonen S / 2007 / Bisphosphonate efficacy and clinical trials for postmenopausal osteoporosis: similarities and differences / Bone 40 : S26 ~ S31
Coxon FP / 2003 / The role of prenylated small GTP binding proteins in the regulation of osteoclast function / Calcif Tissue Int 72 : 80 ~ 84
Coxon FP / 2005 / Phosphonocarboxylate inhibitors of Rab geranylgeranyl transferase disrupt the prenylation and membrane localization of Rab proteins in osteoclasts in vitro
Black DM / 2007 / Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis / N Engl J Med 356 : 1809 ~ 1822
Boonen S / 2007 / Bisphosphonate efficacy and clinical trials for postmenopausal osteoporosis: similarities and differences / Bone 40 : S26 ~ S31
Coxon FP / 2003 / The role of prenylated small GTP binding proteins in the regulation of osteoclast function / Calcif Tissue Int 72 : 80 ~ 84
Coxon FP / 2005 / Phosphonocarboxylate inhibitors of Rab geranylgeranyl transferase disrupt the prenylation and membrane localization of Rab proteins in osteoclasts in vitro
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경구 bisphosphonate를 복용하는 환자에서 발생한 bisphosphonate-related osteonecrosis of jaw에 대한 임상적 특징 및 처치: 증례보고
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Effect of alendronate on bone remodeling around implant in the rat
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Bisphosphonate를 복용하는 환자에게 임프란트 치료시 고려사항
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2011 .07
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Comparison of the efficacy of three once-weekly bisphosphonates on bone mineral density gains in Korean women
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2013 .01
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Bisphosphonate가 흰쥐 치아 및 이틀뼈 성장에 미치는 영향
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2005 .06
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Bisphosphonate 연관 악골 괴사에 의해 발생한 부비동염 1예
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Bisphosphonate-related osteonecrosis of jaw의 치료에 대한 고찰
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The Frequency of and Risk Factors for the Use of Bisphosphonates in the Adjuvant Setting of Primary Breast Cancer in Germany
Cancer Research and Treatment
2015 .01
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수술적 치료를 받은 골다공증성 원위 요골 골절 환자에서 경구용 및 정주용 Bisphosphonate의 사용이 미치는 영향
OSTEOPOROSIS
2013 .01
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Insufficiency Fracture of Ipsilateral Femur Neck in Patient Treated with Long Term Bisphosphonate Treatment - A Case Report -
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2012 .01
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비스포스포네이트 관련 악골괴사의 진단 및 치료에 대한 임상적 연구
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2011 .01
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비스포스포네이트가 코팅된 티타늄 표면의 세포독성 평가
대한치과재료학회지
2011 .03
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유전자 재조합 인간 부갑상선호르몬(1-34)으로 회복된 비스포스포네이트 연관 악골 괴사 증례
OSTEOPOROSIS
2012 .01
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Can Alarming Improve Compliance with Weekly Bisphosphonate in Patients with Osteoporosis?
대한골대사학회지
2016 .01
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Oral Bisphosphonate and Risk of Esophageal Cancer: A Nationwide Claim Study
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2015 .01
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Bisphosphonate와 Indomethacin이 백서 치조골의 골개조에 미치는 영향
대한치과교정학회지
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