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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.3
- 수록면
- 25 - 32 (8page)
- DOI
- 10.14815/kjdm.2011.03.38.1.25
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초록· 키워드
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The aim of this study was to evaluate cytotoxicity of bisphosphonate coated titanium. To coat the bisphosphonate on the titanium, the titanium was modified by anodization and heat-treatment. Then, a biomimetic coating process was completed in two steps. Surface characterization was performed with scanning electron microscopy, energy dispersive spectroscopy, and X-ray Photoelectron spectroscopy. Cytotoxicity was evaluated by MTT assay. After the second coating step, we found that the modified titaniums were formed thick and homogeneous apatite layer that contained the bisphosphonate. Modified titanium were increased the loading of calcium and phosphate ion onto the surface. However, bisphosphonate coated titanium had more cytotoxicity as the concentration of bisphosphonate on the surface was increased. Therefore, these results suggested that further study should be done to demonstrate the effect and safety of this material at the different drug concentration.
목차
ABSTRACT
서론
재료 및 방법
결과
고찰
결론
참고문헌
참고문헌 (24)
참고문헌 신청
1. [학술지(정기간행물)] - Habibovic P / 2002 / Biomimetic hydroxyapatite coating on metal implants / J Am Ceram Soc 85 : 517 ~ 522
2. [학술지(정기간행물)] - Im G-I / 2004 / Osteoblast proliferation and maturation by bisphosphonates / Biomaterials 25 : 4105 ~ 4115
3. [학술지(정기간행물)] - Kajiwara H / 2005 / The bisphosphonate pamidronate on the surface of titanium stimulates bone formation around tibial implants in rats / Biomaterials 26 : 581 ~ 587
4. [학술지(정기간행물)] - Kunze J / 2008 / Time-dependent growth of biomimetic apatite on anodic TiO2 nanotubes / Electrochimica Acta 53 : 6995 ~ 7003
5. [학술지(정기간행물)] - Le Guéhennec L / 2007 / Surface treatments of titanium dental implants for rapid osseointegration / Dental Materials 23 : 844 ~ 854
2. [학술지(정기간행물)] - Im G-I / 2004 / Osteoblast proliferation and maturation by bisphosphonates / Biomaterials 25 : 4105 ~ 4115
3. [학술지(정기간행물)] - Kajiwara H / 2005 / The bisphosphonate pamidronate on the surface of titanium stimulates bone formation around tibial implants in rats / Biomaterials 26 : 581 ~ 587
4. [학술지(정기간행물)] - Kunze J / 2008 / Time-dependent growth of biomimetic apatite on anodic TiO2 nanotubes / Electrochimica Acta 53 : 6995 ~ 7003
5. [학술지(정기간행물)] - Le Guéhennec L / 2007 / Surface treatments of titanium dental implants for rapid osseointegration / Dental Materials 23 : 844 ~ 854
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