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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 충북대학교 동물의학연구소 Journal of Biomedical and Translational Research Journal of Biomedical and Translational Research 제16권 제3호
- 발행연도
- 2015.1
- 수록면
- 109 - 114 (6page)
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초록· 키워드
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Norovirus (NoV) is an etiologic agent of human and animal acute gastroenteritis and is a member of the family Caliciviridae. NoV is classified based on nucleotide sequences of the VP1 gene into at least six genogroups (GI-GVI), among which GI, GII, and GIV are known to infect humans and GII is the most prevalent genogroup. In this study, VP1, the full gene of GII human NoV, was cloned from a human fecal sample and expressed using a baculovirus expression system. Human NoV VP1-specific monoclonal antibodies (MAbs) were produced using expressed recombinant VP1. Expressed VP1 in the recombinant virus was confirmed by polymerase chain reaction (PCR), indirect fluorescence antibody (IFA) test, and Western blot analysis. Eight hybridomas secreting VP1-specific MAbs against human GII NoV were generated and characterized. All of the MAbs produced in this study reacted with human GII NoV VP1-recombinant baculoviruses but not with other non-human calicivirus recombinant baculoviruses. These MAbs reacted specifically with human NoV GII.4-2009 virus-like particles (VLPs), and some MAbs showed cross-reactivity with other GII.4 variant VLPs. Expressed human GII NoV VP1-recombinant protein and MAbs specific to this protein can be used as useful reagents for detecting and characterizing human NoV.
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참고문헌 (25)
참고문헌 신청
5Green KY / 2007 / Fields Virology / Wolters Kluwer Health/Lippincott Williams and Wilkins : 949 ~ 979
Atmar RL / 2001 / Diagnosis of noncultivatable gastroenteritis viruses, the human caliciviruses / Clin Microbiol Rev 14 : 15 ~ 37
Bok K / 2011 / Chimpanzees as an animal model for human norovirus infection and vaccine development / Proc Natl Acad Sci USA 108 : 325 ~ 330
Estes MK / 2006 / Noroviruses everywhere: has something changed? / Curr Opin Infect Dis 19 : 467 ~ 474
Green KY / 1993 / Comparison of the reactivities of baculovirus-expressed recombinant Norwalk virus capsid antigen with those of the native Norwalk virus antigen in serologi
Atmar RL / 2001 / Diagnosis of noncultivatable gastroenteritis viruses, the human caliciviruses / Clin Microbiol Rev 14 : 15 ~ 37
Bok K / 2011 / Chimpanzees as an animal model for human norovirus infection and vaccine development / Proc Natl Acad Sci USA 108 : 325 ~ 330
Estes MK / 2006 / Noroviruses everywhere: has something changed? / Curr Opin Infect Dis 19 : 467 ~ 474
Green KY / 1993 / Comparison of the reactivities of baculovirus-expressed recombinant Norwalk virus capsid antigen with those of the native Norwalk virus antigen in serologi
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