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This study analysed the influence of a 4 week combined weight bearing circuit exercise program in the body composition, physical fitness, and blood profile of an perimenopausal women (aged from 40 ~ 60, N = 29). Significant improvements were found in blood related parameters, fat-related parameters in body compositions and physical fitness parameters (P<0.01). As skeletal muscle mass (SMM) and lean % Dual-energy X-ray absorptiometry (DXA) considered as a standard for muscle mass in this study are used because each standard showed significant differences (P<0.01) and each standard significantly correlated with SMM, weight, time to exhaustion, fat-related parameters such as fa t% DXA, lean % DXA and free fatty acid in pre and post exercise. Blood-related parameters (creatinine, glucose, HDL-cholesterol, and total protein) significantly correlated with changes in each corresponding blood-related parameter after exercise (P=0.000). Exercise contributed to improving muscle mass-related parameters used as biomarkers in this study, which improved the positive changes of healthy indices are indispensable factors for evaluating the effects of exercise. These changes contribute to a virtuous cycle, which accelerates the capacity to perform exercise. It suggests that the weight-bearing circuit exercise can improve the quality of life of perimenopausal women.

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