지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2003.1
- 수록면
- 21 - 26 (6page)
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Backgroun & Objectives : Hyperexciability of motor system is a well-established characteristic pathophysiologic finding of mayotrophic lateral sclerosis (ALS). Whereas little is known about the source of excitability according to the progression of the disease. We evaluated the excitability and its source in advanced ALS patients using transcranial magnetic stimulation(TMS). Material & Methods : Motor evoked potentials (MEP) by TMS were recorded for abductor pollicis brevis muscles in 20 patients, 11men and 9 women, with ALS. Mean age was 54.2?2.1 years, and mean disease duration was 13.9?3.4 years. Serial magnetic stimulations were applied to get the parameters; excitability threshold (ET), amplitude and latency of MEP. We also had a facilitated MEP (fMEP). Results : The parameters were analyzed according to the clinical setting. ET was higher in ALS(mean 63.5?8.1) than normal control (mean 46.0?.4 , p<0.01). Amplitudes of MEP were reduced I ALS (2.6?.6 mV ; control 6.5?.1mV, p<0.01). Duration of the disease and ET showed significant inverse correlation (Spearson correlation coefficient = -0.57, p<0.01). Duration of the disease and fMEP/MEP ratio showed less but also significant inverse correlation(Spearson correlation coefficient, r=-0,52, p<0.05). Conclusions : Lower ET in advanced ALS patients, in spite of decreased fMEP/MEP ratio, may indicate the hyperexcitability of lower motor neuron in these patients. This study suggests that lower motor neurons is hyperexciable due to upper motor neuron dysfunction at advanced stage.
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