지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 125 - 129 (5page)
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Background and Purpose We compared the levels of serum lipid, protein, and glucose between patients with amyotrophic lateral sclerosis (ALS) and healthy controls.
Methods The serum levels of lipids [including triglycerides, cholesterol, low-density lipoprotein (LDL), and high-density lipoprotein (HDL)], protein, and glucose of 95 patients with ALS (60 men) were compared with those of 99 age- and sex-matched healthy controls (64 men).
Both groups had normal dietary intakes.
Results Total cholesterol (p=0.004), LDL (p=0.040), triglyceride (p=0.025), and protein (p=0.010) levels, and LDL/HDL ratios (p<0.001) in men with ALS were significantly lower than those in their control counterparts. There were no such significant differences in these parameters between female patients with ALS and female controls.
Conclusions The serum levels of lipid and protein were significantly lower in male patients with ALS than in the male controls. Since we controlled for the confounding effects of dietary intake, hypolipidemia in ALS might be associated with the pathophysiology of the disease rather than being the result of the decreased dietary intake in ALS patients. Metabolic demand might increase in ALS, and it may be affected by gender.
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참고문헌 (23)
참고문헌 신청
Alves CJ / 2011 / Early motor and electrophysiological changes in transgenic mouse model of amyotrophic lateral sclerosis and gender diffe
Andersson S / 2005 / Inactivation of liver X receptor beta leads to adult-onset motor neuron degeneration in male mice / Proc Natl Acad Sci U S A 102 : 3857 ~ 3862
Appel SH / 2011 / The microglial-motoneuron dialogue in ALS / Acta Myologica 30 : 4 ~ 8
Bouteloup C / 2009 / Hypermetabolism in ALS patients: an early and persistent phenomenon / Journal of Neurology 256 : 1236 ~ 1242
Brooks BR / 2000 / El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis / Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorder
Andersson S / 2005 / Inactivation of liver X receptor beta leads to adult-onset motor neuron degeneration in male mice / Proc Natl Acad Sci U S A 102 : 3857 ~ 3862
Appel SH / 2011 / The microglial-motoneuron dialogue in ALS / Acta Myologica 30 : 4 ~ 8
Bouteloup C / 2009 / Hypermetabolism in ALS patients: an early and persistent phenomenon / Journal of Neurology 256 : 1236 ~ 1242
Brooks BR / 2000 / El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis / Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorder
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