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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 45 - 50 (6page)
이용수
초록· 키워드
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Objectives: In this study, we investigated the 4-weekrepeated-dose oral toxicity of gami-jakyak gamcho bujadecoction (Mecasin) to develop safe treatments.
Methods: In order to investigate the 4-week oral toxicityof Mecasin, we administered Mecasin orally to rats.
Sprague-Dawley (SD) rats were divided into four groupsof five male and five female animals per group: group 1being the control group and groups 2, 3, and 4 being theexperimental groups. Doses of Mecasin of 500, 1,000,and 2,000 mg/kg of body weight were administered tothe experimental groups, and a dose of normal salinesolution of 10 mL/kg was administered to the controlgroup. We examined the survival rate, weight, clinicalsigns, and gross findings for four weeks. This study wasconducted under the approval of the Institutional AnimalEthics Committee.
Results: No deaths occurred in any of the four groups.
No significant changes in weights or food consumptionbetween the control group and the experimentalgroups were observed. Serum biochemistry revealedthat some groups showed significant decrease in inorganicphosphorus (IP) (P < 0.05). During necropsyon the rats, one abnormal macroscopic feature, a slightloss of fur, was observed in the mid dosage (1,000 mg/kg) male group. No abnormalities were observed inany other rats. In histopathological findings, the tubularbasophilia and cast of the kidney and extramedullaryhematopoiesis of the spleen were found. However,those changes were minimal and had occurred naturallyor sporadically. No other organ abnormalitieswere observed.
Conclusion: During this 4-week, repeated, oral toxicitytest of Mecasin in SD rats, no toxicity changes dueto Mecasin were observed in any of the male or the femalerats in the high dosage group. Thus, we suggestthat the doses in a 13-week, repeated test should be 0,500, 1,000, and 2,000 mg/kg respectively.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Elinav E / 2003 / Licorice consumption causing severe hypokalemic paralysis / Mayo Clin Proc 78 (6) : 767 ~ 768
Guo L / 2007 / Orthogonal array design for optimizing extraction efficiency of active constituents from jakyak-gamcho decoction, the complex formula of herbal medicines, Paeo
JaeKyoun Kim / 2012 / Study of Single-dose Toxicity of Aconitum Kusnezoffii Reichb. Pharmacopuncture in Rats / Journal of Pharmacopuncture 15 (3) : 48 ~ 52
Jeong SH / 1997 / The analgesic and anti-imflamatory effect of A.I.P.R aqua-acupuncture on the arthritis induced by freund’s complete adjuvant in rats / The Acupuncture 14
Kang TH / 2005 / Protective effect of jakyak-gamcho-tang extract and its constituents against t-BHP-induced oxidative damage in HT22 cells / Am J Chin Med 33 (2) : 181 ~ 189
Guo L / 2007 / Orthogonal array design for optimizing extraction efficiency of active constituents from jakyak-gamcho decoction, the complex formula of herbal medicines, Paeo
JaeKyoun Kim / 2012 / Study of Single-dose Toxicity of Aconitum Kusnezoffii Reichb. Pharmacopuncture in Rats / Journal of Pharmacopuncture 15 (3) : 48 ~ 52
Jeong SH / 1997 / The analgesic and anti-imflamatory effect of A.I.P.R aqua-acupuncture on the arthritis induced by freund’s complete adjuvant in rats / The Acupuncture 14
Kang TH / 2005 / Protective effect of jakyak-gamcho-tang extract and its constituents against t-BHP-induced oxidative damage in HT22 cells / Am J Chin Med 33 (2) : 181 ~ 189
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