A Study on Single Dose Toxicity of Mecasin Pharmacopuncture Injection in Muscle

Eunhye Cha; Hohyun Jeong; Jongchul Lee; Seongjin Lee; Manyong Park; Sungchul Kim

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자료유형: 학술저널

저자정보: Eunhye Cha (Wonkwang University Gwangju Korean Medical Hospital) Hohyun Jeong (Wonkwang University Gwangju Korean Medical Hospital) Jongchul Lee (Wonkwang University Gwangju Korean Medical Hospital) Seongjin Lee (Wonkwang University Gwangju Korean Medical Hospital) Manyong Park (Wonkwang University Gwangju Korean Medical Hospital) Sungchul Kim (Wonkwang University Gwangju Korean Medical Hospital)

저널정보: 대한한의학회 대한한의학회지 대한한의학회지 제36권 제2호

발행연도: 2015.6

수록면: 36 - 42 (7page)

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Objectives: This study was carried out to analyze the single dose toxicity of Mecasin(Gami-Jakyak Gamcho buja Decoction) pharmacopuncture in muscle of Sprague-Dawley rats.
Methods: All experiments were performed at the Medvill, an institution acknowledged to conduct non-clinical studies, under the Good Laboratory Practice (GLP) regulations. Sprague-Dawley rats were chosen in this pilot study. The reason Sprague-Dawley rats were chosen is that they have been widely used in safety test in the field of medicine, so the results can be easily compared with many other databases. Doses of Mecasin pharmacopuncture, 0, 500, 1,000, and 2,000mg/kg, were registered to the experimental groups, and a dose of normal saline solution, 10 ml/kg, was registered to the control group. Mecasin pharmacopuncture and normal saline were injected into the thigh of the rats by disposable syringes at intervals of six hours twice a day. This study was performed under the approval of the Institutional Animal Ethic Committee.
Results: There is no death or abnormality in any of the four groups. No significant changes in weight, hematological parameters or clinical chemistry between the control group and the experimental groups were observed. To inspect abnormalities in organs and tissues, we used microscopy to examine representative histological sections of each specified organ; the results showed no significant differences in any of the organs or tissues.
Conclusion: The above outcomes suggest that treatment with Mecasin pharmacopuncture is relatively safe. Further evaluations and studies on this subject are needed to prove more concrete evidence.

#Mecasin #pharmacopuncture #intramuscular injection #toxicity test

참고문헌 (20)

참고문헌 신청

1. [학술지(정기간행물)] - 정호현 / 2014 / A Study on the Oral Toxicity of Mecasin in Rats / Journal of Pharmacopuncture 17 (4) : 61 ~ 65

2. [단행본] - Han TR / 2011 / Rehabilitation medicine / Gun-ja : 697 ~

3. [학술지(정기간행물)] - / 2011 / Pain in Amyotrophic Lateral Sclerosis : a psychological perspective / Neurological Science 33 (5) : 1193 ~

4. [학술지(정기간행물)] - Kang TH / 2005 / Protective effect of jakyak-gamcho-tang extract and its constituents against t-BHP-induced oxidative damage in HT22 cells / Am J Chin Med 33 (2) : 181 ~ 189

5. [학술지(정기간행물)] - 이정민 / 2013 / Papain으로 유도된 골관절염 생쥐 모델에서 芍藥甘草附子湯의 항골관절염 효능에 관한 연구 / 대한한의학회지 34 (1) : 116 ~ 135

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