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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 192 - 199 (8page)
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초록· 키워드
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Objectives: KCHO-1(Mecasin), also called Gamijakyakgamchobuja-tang originally, is a combination of some traditional herbal medicines in East Asia. This medicine has been used mainly for alleviating neuropathic pains for centuries in Korean traditional medicine. KCHO-1 was developed to treat pain, joint contracture and muscular weakness in patients with amyotrophic lateral sclerosis. This study was carried out to investigate the chronic toxicity of KCHO-1 oral administration in rats for 26 weeks. Methods: Sprague-Dawely rats were divided into four groups and 10 rats were placed in the control group and the high-dose group, respectively. Group 1 was the control group and the remaining groups were the experimental groups. In the oral toxicity study, 500 mg/ kg, 1,000 mg/kg, and 2,000 mg/kg of KCHO-1 were administered to the experimental group, and 10 ml/kg of sterile distilled water was administered to the control group. Survival rate, body weight, feed intake, clinical signs, and visual findings were examined. Urinalysis, ophthalmologic examination, necropsy, organ weight, hematologic examination, blood chemical examination and histopathologic examination were performed. Results: Mortality and toxicological lesions associated with the administration of test substance were not observed in all groups. Conclusion: NOAEL(No observed adverse effect level) of KCHO-1 is higher than 2000 mg/kg/day. And, the above findings suggest that treatment with KCHO-1 is relatively safe.
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참고문헌 (35)
참고문헌 신청
차은혜 / 2015 / A 4-week Repeated dose Oral Toxicity Study of Mecasin in Sprague-Dawley Rats to Determine the Appropriate Doses for a 13-week, Repeated Toxicity Test / Journal of Pharmacopuncture 18(4):45~50
최은영 / 2002 / 백출 추출물의 세포독성과 항균효과검색 / 동의생리병리학회지 16(2):23~352
추한나 / 2012 / 천마의 건조 조건에 따른 기능 성분과 항산화활성 및 관능적 특성의 효과 / 대한본초학회지 27(6):139~145
Fang YS / 2009 / Effect of constituents from Fructus Aurantii Immaturus and Radix Paeoniae Alba on gastrointestinal movement / Planta. Med 75:24~31
Guo L / 2007 / Orthogonal array design for optimizing extraction efficiency of active constituents from Jakyak-Gamcho Decoction, the complex formula of herbal medicines, Paeoniae Radix and Glycyrrhizae Radix / J Ethnopharmacol 113:306~311
최은영 / 2002 / 백출 추출물의 세포독성과 항균효과검색 / 동의생리병리학회지 16(2):23~352
추한나 / 2012 / 천마의 건조 조건에 따른 기능 성분과 항산화활성 및 관능적 특성의 효과 / 대한본초학회지 27(6):139~145
Fang YS / 2009 / Effect of constituents from Fructus Aurantii Immaturus and Radix Paeoniae Alba on gastrointestinal movement / Planta. Med 75:24~31
Guo L / 2007 / Orthogonal array design for optimizing extraction efficiency of active constituents from Jakyak-Gamcho Decoction, the complex formula of herbal medicines, Paeoniae Radix and Glycyrrhizae Radix / J Ethnopharmacol 113:306~311
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