지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한치매학회 Dementia and Neurocognitive Disorders(대한치매학회지) Dementia and Neurocognitive Disorders(대한치매학회지) 제17권 제4호
- 발행연도
- 2018.1
- 수록면
- 131 - 136 (6page)
이용수
초록· 키워드
오류제보하기
Alzheimer's disease (AD) related genes have been elucidated by advanced genetic techniques. Familial autosomal dominant AD genes founded by linkage analyses are APP , PSEN1 , PSEN2 , ABCA7 , and SORL1 . Genome-wide association studies have found risk genes such as ABCA7 , BIN1 , CASS4 , CD33 , CD2AP , CELF1 , CLU , CR1 , DSG2 , EPHA1 , FERMT2 , HLA-DRB5-HLA-DRB1 , INPP5D , MEF2C , MS4A6A/MS4A4E , NME8 , PICALM , PTK2B , SLC24A4 , SORL1 , and ZCWPW1 . ABCA7 , SORL1 , TREM2 , and APOE are proved to have high odds ratio (>2) in risk of AD using next generation sequencing studies. Thanks to the promising genetic techniques such as CRISPR-CAS9 and single-cell RNA sequencing opened a new era in genetics. CRISPR-CAS9 can directly link genetic knowledge to future treatment. Single-cell RNA sequencing are providing useful information on cell biology and pathogenesis of diverse diseases.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Klein RJ / 2005 / Complement factor H polymorphism in age-related macular degeneration / Science 308:385~389
Lambert JC / 2013 / Meta-analysis of 74,046individuals identifies 11 new susceptibility loci for Alzheimer's disease / Nat Genet 45:1452~1458
Jonsson T / 2013 / Variant of TREM2associated with the risk of Alzheimer's disease / N Engl J Med 368:107~116
Jonsson T / 2012 / A mutation in APP protects against Alzheimer's disease and age-related cognitive decline / Nature 488:96~99
Dickson SP / 2010 / Rare variants create synthetic genome-wide associations / PLoS Biol 8:e1000294
Lambert JC / 2013 / Meta-analysis of 74,046individuals identifies 11 new susceptibility loci for Alzheimer's disease / Nat Genet 45:1452~1458
Jonsson T / 2013 / Variant of TREM2associated with the risk of Alzheimer's disease / N Engl J Med 368:107~116
Jonsson T / 2012 / A mutation in APP protects against Alzheimer's disease and age-related cognitive decline / Nature 488:96~99
Dickson SP / 2010 / Rare variants create synthetic genome-wide associations / PLoS Biol 8:e1000294
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