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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 70 - 82 (13page)
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초록· 키워드
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Objective : The purpose of this study is to examine the effects of Baickbujasan(BB) on the skin damage and
depigmentation.
Method : The inhibition of tyrosinase activity, melanogenesis and cell viability in cultured B16 melanoma cells
were measured. In order to test effects of reduction of melanogenesis, B16 F-10 mouse melanoma stem line was
employed to extract melanin from cultured cell, where BB was added or not, and was dissolved in alkali for
colorimetric analysis.
Also, in order to test skin alteration in C57BL/6 after UV irradiation, the animals were grouped into a UV
urradiation group and UV irradiation after BB application group. Dopa oxidase tissue staining was excuted to
invesitage the change in the distribution of active melanin cell.
The distribution of active melanin cell in inner skin of iNOS after damage from UVB irradiation and the
manifestation condition of P53 which takes part in natural death of keratinocyte were examined.
Result : The results indicate that BB has significant effects on tyrosinase activity, and melanogenesis in vivo
test. BB seems to reduce C57BL/6, external dermatological damage, for instance, erythematous papule, eczema,
loss of keratinocyte, reduction in pus, and relieves dermatological damages.
Conclusion : BB can be applied externally for UV protection and depigmentation.
목차
등록된 정보가 없습니다.
참고문헌 (44)
참고문헌 신청
/ 1998 / 한약재 규격화 모형 설정에 관한 연구 / 경원대학교 한의학연구원 : 133 ~
/ 1998 / 한약재 규격화 모형 설정에 관한 연구 / 경원대학교 한의학연구원 : 162 ~
?廷賢 / 1993 / 萬病回春 / 서울:醫聖堂 : 271 ~
Acroca P / 1992 / Regulation of final mammalian melanogenesis. The role of dopachrome tautomerase and the ratio between 5,6-dihydroxyindole-2- carboxylic acid and 5,6-dihydr
Ando S / 1993 / Tyrosinase gene transcription and its control by melanogenic inhibitors / J Invest Dermatol 100 : 150S ~ 155S
/ 1998 / 한약재 규격화 모형 설정에 관한 연구 / 경원대학교 한의학연구원 : 162 ~
?廷賢 / 1993 / 萬病回春 / 서울:醫聖堂 : 271 ~
Acroca P / 1992 / Regulation of final mammalian melanogenesis. The role of dopachrome tautomerase and the ratio between 5,6-dihydroxyindole-2- carboxylic acid and 5,6-dihydr
Ando S / 1993 / Tyrosinase gene transcription and its control by melanogenic inhibitors / J Invest Dermatol 100 : 150S ~ 155S
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