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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 36 - 51 (16page)
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초록· 키워드
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Objective : This study investigated the effects of PR(Pinelliae Rhizoma) on gene expression of lung tissue
resected from asthma induced mice using intra-nasal instillation.
Methods : Gene expression levels were measured using a microarray technique, and a functional analysis
on these genes was conducted.
Results : A total of 3270 genes were up-regulated or down-regulated, 860 genes which were lowered by
induction of asthma were restored to those of naive animals, Furthermore hand, 1235 genes were lowered
to normal levels, which were elevated by induction of asthma. Most of changed genes were involved in
signalling pathways. Genes in which expression levels were restored by oral administration of PR were
involved in MAPK pathway, focal adhesion, and regulation of actin cytoskeleton etc. Genes of which
expression levels were lowered by oral administration of PR were involved in rhodopsin-like receptor
activity, zinc ion binding and ATP binding. These genes were also involved in neuroactive ligand receptor
interaction, the JAK-STAT signaling pathway and also the T-cell receptor signaling pathway.
Conclusion : These results demonstrate the strong possibility that the mechanisms of PR on asthma are
involved in neuroactive ligand receptor interaction pathway or related molecules.
목차
등록된 정보가 없습니다.
참고문헌 (42)
참고문헌 신청
/ 1996 / 神農本草經 / 北京;科學技術文獻出版社 : 92 ~ 3
Florell SR / 2001 / Preservation of RNA for functional genomic studies: a multidisciplinary tumor bank protocol / Mod Pathol 14 (2) : 116 ~ 28
Hoheisel JD / 2006 / Microarray technology: beyond transcript profiling and genotype analysis / Nat Rev Genet 7 (3) : 200 ~ 10
Kwon KH / 2006 / Analysis of gene expression profiles in cholesteatoma using oligonucleotide microarray / Acta Otolaryngol 126 (7) : 691 ~ 7
Page GP / 2007 / Microarray analysis / Methods Mol Biol 404 : 409 ~ 30
Florell SR / 2001 / Preservation of RNA for functional genomic studies: a multidisciplinary tumor bank protocol / Mod Pathol 14 (2) : 116 ~ 28
Hoheisel JD / 2006 / Microarray technology: beyond transcript profiling and genotype analysis / Nat Rev Genet 7 (3) : 200 ~ 10
Kwon KH / 2006 / Analysis of gene expression profiles in cholesteatoma using oligonucleotide microarray / Acta Otolaryngol 126 (7) : 691 ~ 7
Page GP / 2007 / Microarray analysis / Methods Mol Biol 404 : 409 ~ 30
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