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자료유형
학술저널
저자정보
Pie, Jae-Eun (Department of Food and Nutrition, College of Science and Engineering, Anyang University) Kim, Yu-Ri (Department of Biochemistry & Molecular Biology, Korea University, College of Medicine) Kim, In-Kyoung (Department of Biochemistry & Molecular Biology, Korea University, College of Medicine) Seo, Sang-Hui (Department of Biochemistry & Molecular Biology, Korea University, College of Medicine) Lee, Seung-Ho (Department of Biochemistry & Molecular Biology, Korea University, College of Medicine) Lee, Hee-Ra (Department of Biochemistry & Molecular Biology, Korea University, College of Medicine) Yoo, Young (Research Center for Environment and Health, Korea University Anam Hospital) Chung, Ji-Tae (Research Center for Environment and Health, Korea University Anam Hospital) Youn, Jong-Pil (GenoCheek CO., LTD., Hanyang University) Oh, Moon-Ju (GenoCheek CO., LTD., Hanyang University) Hwang, Seung-Yong (GenoCheek CO., LTD., Hanyang University) Kim, Meyoung-Kon (Department of Biochemistry & Molecular Biology, Korea University, College of Medicine)
저널정보
대한독성유전단백체학회 Molecular & cellular toxicology Molecular & cellular toxicology 제6권 제3호
발행연도
2010.1
수록면
313 - 319 (7page)

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Asthma is a complex inflammatory disease and its prevalence has increased worldwide, especially in young children. In this study, we used a '24-hour recall method' to identify differences between children with and without asthma in energy intake and energy-adjusted nutrition intake. We also performed reverse transcription-polymerase chain reaction (RT-PCR) with pathway-targeted arrays (RT2 $Profiler^{TM}$ PCR Array) to investigate the expression profiles of chemokines and cytokines in children with asthma. The intake of vitamin C in mild and moderate asthma was significantly higher than that in healthy controls. Vitamin E intake in the mild asthma group was also significantly higher. Twenty-three genes were expressed at higher levels in severe asthma compared with healthy controls. Using the human Th1-Th2-Th3 PCR Array, we found 17 genes were upregulated in severe asthma, including the Th2-related genes CCL7, IL13, and CCL-11 (eotaxin). These PCR Array results revealed that the genes that were most profoundly increased in asthma encoded for key proinflammatory and chemotactic molecules. Our observations lead us to speculate that the interaction between gene expression and dietary intake is important for the development of asthma.

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