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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 34 - 54 (21page)
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초록· 키워드
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The effects of four extracts of medicinal herbs, Rubus coreanum, Acorus calamus, Morus alba and Rehmannia glutinosa
on hair growth activity and acnes control were investigated. In the course of screening natural extracts for hair growth, we
found that the extract of dried root of Rubus coreanum has the hair growth promoting effect. After topical application of
these extracts to the back of C57BL/6 mice, the earlier conversion of telogen-to-anagen phase was induced. The growth of
dermal papilla cells and mouse vibrissae hair follicle cultured in vitro, however, was not affected by treatment of these
extracts. Furthermore these extracts do not possesspotent inhibitory effect on 5α-reductase I and II activity and
anti-bacterial effect on Escherichia coli , Propionibacterium acnes, Pityrosporum ovale, Staphylococcus aureus,
Staphylococcus epidermidis, and Candida albicans. RT-PCR analysis showed that these extracts did notinduce mRNA levels
of growth factors such as insulin-like growth factor-I, keratinocyte growth factor, hepatocyte growth factor and vascular
endothelial growth factor in dermal papilla cells. These results suggest that Rubus coreanum has hair growth promoting
effect. However, the effects of these materials on the hair growth promotion are not mediated through inhibition of 5α
-reductase I and II activity, stimulation of hair follicle cells and expression of growth factors in the dermal papilla cells.
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