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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 1,643 - 1,650 (8page)
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초록· 키워드
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Purpose: Bone metastasis invariably increases morbidity and mortality. This study compares the effects of ibandronate and paclitaxelon bone structure and its mechanical properties and biochemical turnover in resorption markers using an immunocompetentWalker 256-Sprague-Dawley model, which was subjected to tumor-induced osteolysis.
Materials and Methods: Seventy rats were divided equally into 4 groups: 1) sham group (SHAM), 2) tumor group (CANC), 3) ibandronate treated group (IBAN), and 4) paclitaxel treated group (PAC). Morphological indices [bone volume fraction (BV/TV), trabecular number (Tb.N), trabecular thickness (Tb.Th), trabecular separation (Tb.Sp)] and mechanical properties (failure load, stiffness) were evaluated after thirty days of treatment period. Bone resorption rate was analysed using serum deoxypyridinoline (Dpd) concentrations.
Results: Morphological indices showed that ibandronate (anti-resorptive drug) had a better effect in treating tumor-induced architecturalchanges in bone than paclitaxel (chemotherapeutic drug). The deterioration in bone architecture was reflected in the biomechanical properties of bone as studied with decreased failure load (Fx) and stiffness (S) of the bone on the 30th day post-surgery. Dpd concentrations were significantly lower in the IBAN group, indicating successful inhibition of bone resorption and destruction.
Conclusion: Ibandronate was found to be as effective as higher doses of paclitaxel in maintaining stiffness of bone. Paclitaxel treatment did not appear to inhibit osteoclast resorption, which is contrary to earlier in-vitro literature. Emphasis should be placed on the use of immunocompetent models for examining drug efficacy since it adequately reflects bone metastasis in clinicalscenarios.
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참고문헌 (48)
참고문헌 신청
Fleisch H / 1996 / The bisphosphonate ibandronate, given daily as well as discontinuously, decreases bone resorption and increases calcium retention as assessed by 45Ca kinetics in the intact rat / Osteoporos Int 6:166~170
Chen X / 2013 / Localized sclerotic bone response demonstrated reduced nanomechanical creep properties / J Mech Behav Biomed Mater 17:198~208
Xiao Yang / 2010 / Morphological and Mechanical Changes in Ovariectomized Rat Tibia with Treatments of Ibandronate and Parathyroid Hormone / OSTEOPOROSIS 8(3):255~265
이태용 / 2011 / Effect of Ibandronate and hPTH on the Viscoelastic Response of Ovariectomized Rat Femur / OSTEOPOROSIS 9(3):222~230
Allen MJ / 2003 / Biochemical markers of bone metabolism in animals:uses and limitations / Vet Clin Pathol 32:101~113
Chen X / 2013 / Localized sclerotic bone response demonstrated reduced nanomechanical creep properties / J Mech Behav Biomed Mater 17:198~208
Xiao Yang / 2010 / Morphological and Mechanical Changes in Ovariectomized Rat Tibia with Treatments of Ibandronate and Parathyroid Hormone / OSTEOPOROSIS 8(3):255~265
이태용 / 2011 / Effect of Ibandronate and hPTH on the Viscoelastic Response of Ovariectomized Rat Femur / OSTEOPOROSIS 9(3):222~230
Allen MJ / 2003 / Biochemical markers of bone metabolism in animals:uses and limitations / Vet Clin Pathol 32:101~113
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