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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 11 - 18 (8page)
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초록· 키워드
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Objectives: The favorable safety and consistent effectiveness of monthly intravenous (IV) ibandronate injections was demonstrated in a prospective, postmarketing, observational study in Japanese patients with osteoporosis. Here, we present subgroup analyses from the study. Methods: Lumbar spine (L2e4) bone mineral density (BMD) gains were assessed in the following subgroups: aged <75 or 75 years, absence or presence of vertebral fractures, previous bisphosphonate (BP) treatment, and concomitant versus naïve osteoporosis drug treatment. The cumulative incidence of fractures and relative change in bone turnover markers were also examined. Results: Of 1062 enrolled patients, 1025 received monthly IV ibandronate 1mg and were assessed for 12 months. BMD gains with ibandronate were comparable, irrespective of older age or prevalent fractures. Overall, 515 patients (50.2%) had previously received osteoporosis treatment; of these, 166 (16.1%) received other BPs. Mean BMD changes were 3.69% (95% confidence interval [CI], 0.89%e6.50%) in patients previously treated with other BPs, and 4.26% (95% CI, 2.88%e5.64%) in patients who had not received prior osteoporosis treatment. Among the 510 patients (49.7%) concomitantly prescribed active vitamin D drugs, mean BMD changes were 5.74% (95% CI, 2.53%e8.95%) with eldecalcitol versus 3.54% (95% CI, 1.98%e5.10%) with ibandronate alone. The lowest fracture incidence was observed with the combination of ibandronate and eldecalcitol, but differences between the subgroups were not statistically significant. Conclusions: Monthly IV ibandronate demonstrated comparable BMD gains in the patient subgroups analyzed. Concomitant use of ibandronate with eldecalcitol showed a trend of higher BMD gains and lower fracture incidence than ibandronate alone.
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참고문헌 (22)
참고문헌 신청
Reginster JY / 2006 / Efficacy and tolerability of once-monthly oral ibandronate in postmenopausal osteoporosis : 2 year results from the MOBILE study / Ann Rheum Dis 65:654~661
Eisman JA / 2008 / Efficacy and tolerability of intravenous ibandronate injections in postmenopausal osteoporosis : 2-year results from the DIVA study / J Rheumatol 35:488~497
Miller PD / 2012 / Efficacy of monthly oral ibandronate is sustained over 5 years : the MOBILE long-term extension study / Osteoporos Int 23:1747~1756
Bianchi G / 2012 / Long-term administration of quarterly IV ibandronate is effective and well tolerated in postmenopausal osteoporosis : 5-year data from the DIVA study long-term extension / Osteoporos Int 23:1769~1778
Harris ST / 2008 / Ibandronate and the risk of nonvertebral and clinical fractures in women with postmenopausal osteoporosis : results of a meta-analysis of phase III studies / Curr Med Res Opin 24:237~245
Eisman JA / 2008 / Efficacy and tolerability of intravenous ibandronate injections in postmenopausal osteoporosis : 2-year results from the DIVA study / J Rheumatol 35:488~497
Miller PD / 2012 / Efficacy of monthly oral ibandronate is sustained over 5 years : the MOBILE long-term extension study / Osteoporos Int 23:1747~1756
Bianchi G / 2012 / Long-term administration of quarterly IV ibandronate is effective and well tolerated in postmenopausal osteoporosis : 5-year data from the DIVA study long-term extension / Osteoporos Int 23:1769~1778
Harris ST / 2008 / Ibandronate and the risk of nonvertebral and clinical fractures in women with postmenopausal osteoporosis : results of a meta-analysis of phase III studies / Curr Med Res Opin 24:237~245
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