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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 697 - 703 (7page)
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Purpose: Adenosine triphosphate-based chemotherapy response assay (ATP-CRA) is a well-documented and
validated technology that can individualize chemotherapy for patients with lung, stomach, or breast cancer. This
study explored the feasibility of ATP-CRA as a chemosensitivity test in patients with colorectal cancer. Materials
and Methods: A total of 118 patients who underwent surgical resection for colorectal adenocarcinoma were
analyzed for chemosensitivity to 6 anticancer drugs using ATP-CRA. We calculated the cell death rate (CDR) by
measuring intracellular ATP levels of drug-exposed cells and untreated controls. Results: Interpretable results were
available for 85.5% (118/138) of patients. The mean coefficient of variation for triplicate ATP measurements was
9.2%. The highest CDR was observed in irinotecan (34.0%) and the lowest CDR in etoposide (21.0%). Paclitaxel
had the broadest range of CDR (0-86.7%) and 5-FU had the narrowest range of CDR (0-56.8%). The overall
highest responsiveness was seen most prevalently in irinotecan (24.7%, 23/93 patients). Irinotecan had the greatest
responsiveness in patients with well differentiated and moderately differentiated carcinoma. Conclusion: Our study
suggests that ATP-CRA could be used to identify patients with colorectal cancer who might benefit from treatment
with a specific chemotherapeutic agent.
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등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Bird MC / 1985 / In vitro determination of tumour chemosensitivity in haematological malignancies / Hematol Oncol 3 : 1 ~ 10
Bogden AE / 1984 / Predictive testing with the subrenal capsule assay / Cancer Treat Rev 11 (A) : 113 ~ 124
Cortazar P / 1999 / Review of the efficacy of individualized chemotherapy selected by in vitro drug sensitivity testing for patients with cancer / J Clin Oncol 17 : 1625 ~ 16
Cree IA / 1996 / Correlation of the clinical response to chemotherapy in breast cancer with ex vivo chemosensitivity / Anticancer Drugs 7 : 630 ~ 635
Cree IA / 1999 / Heterogeneity of chemosensitivity of metastatic cutaneous melanoma / Anticancer Drugs 10 : 437 ~ 444
Bogden AE / 1984 / Predictive testing with the subrenal capsule assay / Cancer Treat Rev 11 (A) : 113 ~ 124
Cortazar P / 1999 / Review of the efficacy of individualized chemotherapy selected by in vitro drug sensitivity testing for patients with cancer / J Clin Oncol 17 : 1625 ~ 16
Cree IA / 1996 / Correlation of the clinical response to chemotherapy in breast cancer with ex vivo chemosensitivity / Anticancer Drugs 7 : 630 ~ 635
Cree IA / 1999 / Heterogeneity of chemosensitivity of metastatic cutaneous melanoma / Anticancer Drugs 10 : 437 ~ 444
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Predictive Value of In Vitro Adenosine Triphosphate-Based Chemotherapy Response Assay in Advanced Gastric Cancer Patients Who Received Oral 5-Fluorouracil after Curative Resection
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Clinical value of an adenosine triphosphate-based chemotherapy response assay in resectable stage Ⅲ colorectal cancer
Annals of Surgical Treatment and Research
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위암에서 ATP-CRA (Chemotherapy Response Assay)를 이용한 내성약제의 선택
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전이성대장암환자에서 체외 항암약물 감수성 검사와 일차항암화학요법 간의 임상적 연관성
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Thalidomide Combined with Chemotherapy in Treating Patients with Advanced Colorectal Cancer
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2. How can we improve the outcomes of colorectal cancers?_3) Who are high risk patients among stage II colorectal cancers?
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ADJUVANT CHEMOTHERAPY FOR COLORECTAL CANCER
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진행성 위암에서 항암제 감수성 검사
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